3WWR
Crystal structure of the human vitamin D receptor ligand binding domain complexed with 1-((((1S,2R,6R,Z)-2,6-dihydroxy-4-((E)-2-((1R,3aS,7aR)-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-3-methylenecyclohexyl)oxy)methyl)cyclopropanecarbonitrile
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Vitamin D3 receptor | polymer | 263 | 29805.3 | 1 | UniProt (P11473) Pfam (PF00104) In PDB | Homo sapiens (human) | VDR, 1,25-dihydroxyvitamin D3 receptor, Nuclear receptor subfamily 1 group I member 1 |
| 2 | A | 1-({[(1R,2S,3R,5Z,7E,14beta,17alpha)-1,3,25-trihydroxy-9,10-secocholesta-5,7,10-trien-2-yl]oxy}methyl)cyclopropanecarbonitrile | non-polymer | 511.7 | 1 | Chemie (3AJ) |
Sequence modifications
A: 118 - 215 (UniProt: P11473)
A: 216 - 427 (UniProt: P11473)
| PDB | External Database | Details |
|---|---|---|
| Gly 114 | - | expression tag |
| Ser 115 | - | expression tag |
| His 116 | - | expression tag |
| Met 117 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 29805.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 511.7 | |
| All* | Total formula weight | 30317.1 |
