3WWR

Crystal structure of the human vitamin D receptor ligand binding domain complexed with 1-((((1S,2R,6R,Z)-2,6-dihydroxy-4-((E)-2-((1R,3aS,7aR)-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-3-methylenecyclohexyl)oxy)methyl)cyclopropanecarbonitrile

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 3AJ A 501

Chain	Residue
A	TYR143
A	CYS288
A	HIS305
A	HIS397
A	ASP144
A	LEU227
A	VAL234
A	SER237
A	ILE271
A	ARG274
A	SER275
A	SER278

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	Region: {"description":"Interaction with coactivator LXXLL motif","evidences":[{"source":"UniProtKB","id":"P13053","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10678179","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11344298","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1DB1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1IE8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10678179","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11344298","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1DB1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10678179","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11344298","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1IE8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10678179","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11344298","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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