3WV6
Crystal Structure of a protease-resistant mutant form of human galectin-9
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Galectin-9 | polymer | 296 | 33108.6 | 2 | UniProt (O00182) Pfam (PF00337) In PDB | Homo sapiens (human) | Gal-9, Ecalectin, Tumor antigen HOM-HD-21 |
2 | C, E | beta-D-galactopyranose-(1-4)-beta-D-glucopyranose | branched | 342.3 | 2 | In PDB BIRD (PRD_900004) GlyTouCan (G84224TW) | beta-lactose | ||
3 | D, F | beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose | branched | 342.3 | 2 | In PDB BIRD (PRD_900008) GlyTouCan (G88362QR) | alpha-lactose | ||
4 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
5 | A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 10 | Chemie (EDO) | |||
6 | water | water | 18.0 | 596 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 148 (UniProt: O00182)
A, B: 178 - 323 (UniProt: O00182)
A, B: 178 - 323 (UniProt: O00182)
PDB | External Database | Details |
---|---|---|
His 149 | - | SEE REMARK 999 |
Met 150 | - | SEE REMARK 999 |
Ser 221 | Arg 253 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 66217.3 | |
Branched | Number of molecules | 4 |
Total formula weight | 1369.2 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 751.5 | |
All* | Total formula weight | 68337.9 |