3WV6

Crystal Structure of a protease-resistant mutant form of human galectin-9

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Galectin-9	polymer	296	33108.6	2	UniProt (O00182) Pfam (PF00337)	Homo sapiens (human)	Gal-9, Ecalectin, Tumor antigen HOM-HD-21
2	C, E (C, E)	beta-D-galactopyranose-(1-4)-beta-D-glucopyranose	branched		342.3	2	In PDB BIRD (PRD_900004) GlyTouCan (G84224TW)		beta-lactose
3	D, F (D, F)	beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose	branched		342.3	2	In PDB BIRD (PRD_900008) GlyTouCan (G88362QR)		alpha-lactose
4	G, M (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
5	H, I, J, K, L... (A, B)	1,2-ETHANEDIOL	non-polymer		62.1	10	Chemie (EDO)
6	S, T (A, B)	water	water		18.0	596	Chemie (HOH)

Sequence modifications

A, B: 1 - 148 (UniProt: O00182)
A, B: 178 - 323 (UniProt: O00182)

PDB	External Database	Details
His 149	-	SEE REMARK 999
Met 150	-	SEE REMARK 999
Ser 221	Arg 253	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	66217.3
Branched	Number of molecules	4
	Total formula weight	1369.2
Non-Polymers*	Number of molecules	12
	Total formula weight	751.5
All*	Total formula weight	68337.9

*Water molecules are not included.