3WTU
Crystal structure of the complex comprised of ETS1 (V170A), RUNX1, CBFBETA, and the tcralpha gene enhancer DNA
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, F | Runt-related transcription factor 1 | polymer | 204 | 22885.7 | 2 | UniProt (Q03347) Pfam (PF00853) In PDB | Mus musculus (mouse) | Acute myeloid leukemia 1 protein, Core-binding factor subunit alpha-2, CBF-alpha-2, Oncogene AML-1, Polyomavirus enhancer-binding protein 2 alpha B subunit, PEA2-alpha B, PEBP2-alpha B, SL3-3 enhancer factor 1 alpha B subunit, SL3/AKV core-binding factor alpha B subunit |
2 | B, G | Core-binding factor subunit beta | polymer | 142 | 16684.7 | 2 | UniProt (Q08024) Pfam (PF02312) In PDB | Mus musculus (mouse) | CBF-beta, Polyomavirus enhancer-binding protein 2 beta subunit, PEA2-beta, PEBP2-beta, SL3-3 enhancer factor 1 subunit beta, SL3/AKV core-binding factor beta subunit |
3 | C, H | Protein C-ets-1 | polymer | 166 | 19216.7 | 2 | UniProt (P14921) Pfam (PF19525) Pfam (PF00178) In PDB | Homo sapiens (human) | p54 |
4 | D, I | DNA (5'-D(*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*T)-3') | polymer | 15 | 4513.9 | 2 | |||
5 | E, J | DNA (5'-D(*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3') | polymer | 15 | 4665.0 | 2 | |||
6 | water | water | 18.0 | 35 | Chemie (HOH) |
Sequence modifications
A, F: 60 - 263 (UniProt: Q03347)
PDB | External Database | Details |
---|---|---|
Lys 94 | Leu 94 | engineered mutation |
Ala 170 | Val 170 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 10 |
Total formula weight | 135932.4 | |
All* | Total formula weight | 135932.4 |