3WN7

Crystal Structure of Keap1 in Complex with the N-terminal region of the Nrf2 transcription factor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, L)	Kelch-like ECH-associated protein 1	polymer	311	34270.1	2	UniProt (Q9Z2X8) Pfam (PF01344)	Mus musculus (mouse)	Cytosolic inhibitor of Nrf2, INrf2
2	B, D (B, M)	Peptide from Nuclear factor erythroid 2-related factor 2	polymer	35	4334.8	2	UniProt (Q60795)	Mus musculus	NF-E2-related factor 2, NFE2-related factor 2, Nuclear factor, erythroid derived 2, like 2
3	E, F (A, L)	ACETATE ION	non-polymer		59.0	2	Chemie (ACT)
4	G, H, I, J (A, B, L, M)	water	water		18.0	489	Chemie (HOH)

Sequence modifications

A, L: 321 - 609 (UniProt: Q9Z2X8)

PDB	External Database	Details
Met 299	-	expression tag
Gly 300	-	expression tag
His 301	-	expression tag
His 302	-	expression tag
His 303	-	expression tag
His 304	-	expression tag
His 305	-	expression tag
His 306	-	expression tag
Asp 307	-	expression tag
Tyr 308	-	expression tag
Asp 309	-	expression tag
Ile 310	-	expression tag
Pro 311	-	expression tag
Thr 312	-	expression tag
Thr 313	-	expression tag
Glu 314	-	expression tag
Asn 315	-	expression tag
Leu 316	-	expression tag
Tyr 317	-	expression tag
Phe 318	-	expression tag
Gln 319	-	expression tag
Gly 320	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	77209.9
Non-Polymers*	Number of molecules	2
	Total formula weight	118.1
All*	Total formula weight	77328.0

*Water molecules are not included.