3WN7

Crystal Structure of Keap1 in Complex with the N-terminal region of the Nrf2 transcription factor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008134	molecular_function	transcription factor binding
A	0016567	biological_process	protein ubiquitination
A	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0034599	biological_process	cellular response to oxidative stress
L	0008134	molecular_function	transcription factor binding
L	0016567	biological_process	protein ubiquitination
L	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
M	0003677	molecular_function	DNA binding
M	0003700	molecular_function	DNA-binding transcription factor activity
M	0005634	cellular_component	nucleus
M	0005737	cellular_component	cytoplasm
M	0034599	biological_process	cellular response to oxidative stress

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ACT A 701

Chain	Residue
A	VAL465
A	VAL512
A	CYS513
A	ILE559
A	HOH818
A	HOH971
A	HOH972

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site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE ACT L 701

Chain	Residue
L	VAL512
L	CYS513
L	HOH822
L	HOH890
L	HOH891
L	HOH908
L	VAL465
L	ALA466

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000250|UniProtKB:O54968

Chain	Residue	Details
B	SER40
M	SER40

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: S-cGMP-cysteine => ECO:0000269|PubMed:20498371

Chain	Residue	Details
A	CYS434
L	CYS434

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