3WN7
Crystal Structure of Keap1 in Complex with the N-terminal region of the Nrf2 transcription factor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008134 | molecular_function | transcription factor binding |
| A | 0016567 | biological_process | protein ubiquitination |
| A | 0031463 | cellular_component | Cul3-RING ubiquitin ligase complex |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0034599 | biological_process | cellular response to oxidative stress |
| L | 0008134 | molecular_function | transcription factor binding |
| L | 0016567 | biological_process | protein ubiquitination |
| L | 0031463 | cellular_component | Cul3-RING ubiquitin ligase complex |
| M | 0003677 | molecular_function | DNA binding |
| M | 0003700 | molecular_function | DNA-binding transcription factor activity |
| M | 0005634 | cellular_component | nucleus |
| M | 0005737 | cellular_component | cytoplasm |
| M | 0034599 | biological_process | cellular response to oxidative stress |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ACT A 701 |
| Chain | Residue |
| A | VAL465 |
| A | VAL512 |
| A | CYS513 |
| A | ILE559 |
| A | HOH818 |
| A | HOH971 |
| A | HOH972 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE ACT L 701 |
| Chain | Residue |
| L | VAL512 |
| L | CYS513 |
| L | HOH822 |
| L | HOH890 |
| L | HOH891 |
| L | HOH908 |
| L | VAL465 |
| L | ALA466 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 90 |
| Details | Repeat: {"description":"Kelch 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 100 |
| Details | Repeat: {"description":"Kelch 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 92 |
| Details | Repeat: {"description":"Kelch 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 92 |
| Details | Repeat: {"description":"Kelch 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 90 |
| Details | Repeat: {"description":"Kelch 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Site: {"description":"Sensor for electrophilic agents","evidences":[{"source":"PubMed","id":"20498371","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"S-cGMP-cysteine","evidences":[{"source":"PubMed","id":"20498371","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | Motif: {"description":"DLG motif","evidences":[{"source":"PubMed","id":"15581590","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"16581765","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"16790436","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"UniProtKB","id":"O54968","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
