3W8I

Crystal structure of CCM3 in complex with the C-terminal regulatory domain of MST4

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Programmed cell death protein 10	polymer	213	24896.6	1	UniProt (Q9BUL8) Pfam (PF20929) Pfam (PF06840)	Homo sapiens (human)	Cerebral cavernous malformations 3 protein, TF-1 cell apoptosis-related protein 15
2	B (B)	Serine/threonine-protein kinase MST4	polymer	76	8205.4	1	UniProt (Q9P289) Pfam (PF20929)	Homo sapiens (human)	Mammalian STE20-like protein kinase 4, MST-4, Mst3 and SOK1-related kinase, STE20-like kinase MST4, Serine/threonine-protein kinase MASK
3	C, D (A, B)	water	water		18.0	112	Chemie (HOH)

Sequence modifications

A: 8 - 212 (UniProt: Q9BUL8)

PDB	External Database	Details
Leu 213	-	expression tag
Glu 214	-	expression tag
His 215	-	expression tag
His 216	-	expression tag
His 217	-	expression tag
His 218	-	expression tag
His 219	-	expression tag
His 220	-	expression tag

B: 346 - 416 (UniProt: Q9P289)

PDB	External Database	Details
Gly -5	-	expression tag
Pro -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
Met -1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	33102.0
All*	Total formula weight	33102.0

*Water molecules are not included.