3W8H

Crystal structure of CCM3 in complex with the C-terminal regulatory domain of STK25

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Programmed cell death protein 10	polymer	213	24896.6	1	UniProt (Q9BUL8) Pfam (PF20929) Pfam (PF06840)	Homo sapiens (human)	Cerebral cavernous malformations 3 protein, TF-1 cell apoptosis-related protein 15
2	B (B)	Serine/threonine-protein kinase 25	polymer	78	8607.7	1	UniProt (O00506) Pfam (PF20929)	Homo sapiens (human)	Ste20-like kinase, Sterile 20/oxidant stress-response kinase 1, SOK-1, Ste20/oxidant stress response kinase 1
3	C, D, E, F, G... (A, B)	SULFATE ION	non-polymer		96.1	7	Chemie (SO4)
4	J, K (A, B)	water	water		18.0	116	Chemie (HOH)

Sequence modifications

A: 8 - 212 (UniProt: Q9BUL8)

PDB	External Database	Details
Leu 213	-	expression tag
Glu 214	-	expression tag
His 215	-	expression tag
His 216	-	expression tag
His 217	-	expression tag
His 218	-	expression tag
His 219	-	expression tag
His 220	-	expression tag

B: 355 - 426 (UniProt: O00506)

PDB	External Database	Details
Gly -6	-	expression tag
Pro -5	-	expression tag
Gly -4	-	expression tag
Ser -3	-	expression tag
Glu -2	-	expression tag
Phe -1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	33504.3
Non-Polymers*	Number of molecules	7
	Total formula weight	672.4
All*	Total formula weight	34176.7

*Water molecules are not included.