3VZV

Crystal structure of human mdm2 with a dihydroimidazothiazole inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	E3 ubiquitin-protein ligase Mdm2	polymer	87	10205.0	2	UniProt (Q00987) Pfam (PF02201)	Homo sapiens (human)	Double minute 2 protein, Hdm2, Oncoprotein Mdm2, p53-binding protein Mdm2
2	C, D (A, B)	1-{[(5R,6S)-5,6-bis(4-chlorophenyl)-6-methyl-3-(propan-2-yl)-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-N,N-dimethyl-L-prolinamide	non-polymer		571.6	2	Chemie (VZV)

Sequence modifications

A, B: 25 - 109 (UniProt: Q00987)

PDB	External Database	Details
Gly 23	-	expression tag
Ser 24	-	expression tag
Glu 33	Leu 33	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	20409.9
Non-Polymers*	Number of molecules	2
	Total formula weight	1143.1
All*	Total formula weight	21553.1

*Water molecules are not included.