3VV7
Crystal Structure of beta secetase in complex with 2-amino-6-((1S,2R)-2-(3'-methoxybiphenyl-3-yl)cyclopropyl)-3-methylpyrimidin-4(3H)-one
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Beta-secretase 1 | polymer | 416 | 46393.0 | 1 | UniProt (P56817) Pfam (PF00026) In PDB | Homo sapiens (human) | Aspartyl protease 2, ASP2, Asp 2, Beta-site amyloid precursor protein cleaving enzyme 1, Beta-site APP cleaving enzyme 1, Memapsin-2, Membrane-associated aspartic protease 2 |
| 2 | A | IODIDE ION | non-polymer | 126.9 | 6 | Chemie (IOD) | |||
| 3 | A | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 4 | A | 2-amino-6-[(1S,2R)-2-(3'-methoxybiphenyl-3-yl)cyclopropyl]-3-methylpyrimidin-4(3H)-one | non-polymer | 347.4 | 1 | Chemie (0B1) | |||
| 5 | water | water | 18.0 | 212 | Chemie (HOH) |
Sequence modifications
A: -18 - 393 (UniProt: P56817)
| PDB | External Database | Details |
|---|---|---|
| Gly -22 | - | EXPRESSION TAG |
| Ser -21 | - | EXPRESSION TAG |
| His -20 | - | EXPRESSION TAG |
| Met -19 | - | EXPRESSION TAG |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 46393.0 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1293.0 | |
| All* | Total formula weight | 47686.1 |
