3VRQ

Crystal structure of the tyrosine kinase binding domain of Cbl-c (PL mutant)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Signal transduction protein CBL-C	polymer	331	36707.1	2	UniProt (Q9ULV8) Pfam (PF02262) Pfam (PF02761) Pfam (PF02762) In PDB	Homo sapiens (human)	RING finger protein 57, SH3-binding protein CBL-3, SH3-binding protein CBL-C
2	A, B	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)
3		water	water		18.0	120	Chemie (HOH)

Sequence modifications

A, B: 1 - 323 (UniProt: Q9ULV8)

PDB	External Database	Details
Gly -7	-	expression tag
Pro -6	-	expression tag
Leu -5	-	expression tag
Gly -4	-	expression tag
Ser -3	-	expression tag
Pro -2	-	expression tag
Glu -1	-	expression tag
Phe 0	-	expression tag
Leu 265	Pro 265	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	73414.2
Non-Polymers*	Number of molecules	2
	Total formula weight	80.2
All*	Total formula weight	73494.4

*Water molecules are not included.