3VP6

Structural characterization of Glutamic Acid Decarboxylase; insights into the mechanism of autoinactivation

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Glutamate decarboxylase 1	polymer	511	58429.7	2	UniProt (Q99259) Pfam (PF00282)	Homo sapiens (human)	67 kDa glutamic acid decarboxylase, GAD-67, Glutamate decarboxylase 67 kDa isoform
2	C, D (A, B)	4-oxo-4H-pyran-2,6-dicarboxylic acid	non-polymer		184.1	2	Chemie (HLD)
3	E, F (B)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
4	G, H (A, B)	water	water		18.0	266	Chemie (HOH)

Sequence modifications

A, B: 90 - 594 (UniProt: Q99259)

PDB	External Database	Details
His 431	Cys 431	conflict
Ser 433	Gly 433	conflict
Gln 438	Pro 438	conflict
His 441	Gln 441	conflict
His 595	-	expression tag
His 596	-	expression tag
His 597	-	expression tag
His 598	-	expression tag
His 599	-	expression tag
His 600	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	116859.4
Non-Polymers*	Number of molecules	4
	Total formula weight	552.4
All*	Total formula weight	117411.8

*Water molecules are not included.