3VN9

Rifined Crystal structure of non-phosphorylated MAP2K6 in a putative auto-inhibition state

Replaces:  3AN0

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Dual specificity mitogen-activated protein kinase kinase 6	polymer	340	38369.2	1	UniProt (P52564) Pfam (PF00069)	Homo sapiens (human)	MAP kinase kinase 6, MAPKK 6, MAPK/ERK kinase 6, MEK 6, Stress-activated protein kinase kinase 3, SAPK kinase 3, SAPKK-3, SAPKK3
2	B (A)	9-{5-O-[(R)-hydroxy{[(S)-hydroxy(phosphonoamino)phosphoryl]oxy}phosphoryl]-beta-L-ribofuranosyl}-9H-purin-6-amine	non-polymer		506.2	1	Chemie (ANK) PubChem (4795) PubChem (33113) PubChem (23639785) PubChem (24794410) PubChem (44462678) PubChem (46926537) PubChem (54765332) PubChem (60063697) PubChem (66575078) PubChem (6102784) PubChem (9543492) PubChem (445863) PubChem (89688694) PubChem (14188278) PubChem (16058657) PubChem (92436779) PubChem (93005803)
3	C (A)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG) PubChem (888)
4	D (A)	water	water		18.0	18	Chemie (HOH)

Sequence modifications

A: 1 - 334 (UniProt: P52564)

PDB	External Database	Details
His 335	-	expression tag
His 336	-	expression tag
His 337	-	expression tag
His 338	-	expression tag
His 339	-	expression tag
His 340	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	38369.2
Non-Polymers*	Number of molecules	2
	Total formula weight	530.5
All*	Total formula weight	38899.7

*Water molecules are not included.