3VN9

Rifined Crystal structure of non-phosphorylated MAP2K6 in a putative auto-inhibition state

Replaces:  3AN0

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Dual specificity mitogen-activated protein kinase kinase 6	polymer	340	38369.2	1	UniProt (P52564) Pfam (PF00069)	Homo sapiens (human)	MAP kinase kinase 6, MAPKK 6, MAPK/ERK kinase 6, MEK 6, Stress-activated protein kinase kinase 3, SAPK kinase 3, SAPKK-3, SAPKK3
2	B (A)	9-{5-O-[(R)-hydroxy{[(S)-hydroxy(phosphonoamino)phosphoryl]oxy}phosphoryl]-beta-L-ribofuranosyl}-9H-purin-6-amine	non-polymer		506.2	1	Chemie (ANK)
3	C (A)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG) PubChem (888)
4	D (A)	water	water		18.0	18	Chemie (HOH)

Sequence modifications

A: 1 - 334 (UniProt: P52564)

PDB	External Database	Details
His 335	-	expression tag
His 336	-	expression tag
His 337	-	expression tag
His 338	-	expression tag
His 339	-	expression tag
His 340	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	38369.2
Non-Polymers*	Number of molecules	2
	Total formula weight	530.5
All*	Total formula weight	38899.7

*Water molecules are not included.