3VN9
Rifined Crystal structure of non-phosphorylated MAP2K6 in a putative auto-inhibition state
Replaces: 3AN0Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000165 | biological_process | MAPK cascade |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0001649 | biological_process | osteoblast differentiation |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0004708 | molecular_function | MAP kinase kinase activity |
| A | 0004713 | molecular_function | protein tyrosine kinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005856 | cellular_component | cytoskeleton |
| A | 0006351 | biological_process | DNA-templated transcription |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0006915 | biological_process | apoptotic process |
| A | 0007165 | biological_process | signal transduction |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0019901 | molecular_function | protein kinase binding |
| A | 0031098 | biological_process | stress-activated protein kinase signaling cascade |
| A | 0035872 | biological_process | nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway |
| A | 0038066 | biological_process | p38MAPK cascade |
| A | 0042770 | biological_process | signal transduction in response to DNA damage |
| A | 0051403 | biological_process | stress-activated MAPK cascade |
| A | 0051726 | biological_process | regulation of cell cycle |
| A | 0060348 | biological_process | bone development |
| A | 0090398 | biological_process | cellular senescence |
| A | 0106310 | molecular_function | protein serine kinase activity |
| A | 0120163 | biological_process | negative regulation of cold-induced thermogenesis |
| A | 1901796 | biological_process | regulation of signal transduction by p53 class mediator |
| A | 1902531 | biological_process | regulation of intracellular signal transduction |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE ANK A 401 |
| Chain | Residue |
| A | GLY60 |
| A | SER135 |
| A | LYS138 |
| A | ASP179 |
| A | LYS181 |
| A | SER183 |
| A | ASN184 |
| A | ASP197 |
| A | SER201 |
| A | LYS210 |
| A | MG402 |
| A | ALA63 |
| A | TYR64 |
| A | VAL67 |
| A | ALA80 |
| A | LYS82 |
| A | MET129 |
| A | GLU130 |
| A | MET132 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG A 402 |
| Chain | Residue |
| A | ASN184 |
| A | ASP197 |
| A | ANK401 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGAYGVVEkMrhvpsgqi..........MAVK |
| Chain | Residue | Details |
| A | LEU59-LYS82 |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ViHrDVKpsNVLI |
| Chain | Residue | Details |
| A | VAL175-ILE187 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 261 |
| Details | Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 23 |
| Details | Region: {"description":"DVD domain"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by MAP3K; alternate","evidences":[{"source":"PubMed","id":"16728640","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24936062","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine; by MAP3K; alternate","evidences":[{"source":"PubMed","id":"16728640","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24936062","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
