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3VN9

Rifined Crystal structure of non-phosphorylated MAP2K6 in a putative auto-inhibition state

Replaces:  3AN0
Functional Information from GO Data
ChainGOidnamespacecontents
A0000165biological_processMAPK cascade
A0001649biological_processosteoblast differentiation
A0001934biological_processpositive regulation of protein phosphorylation
A0002931biological_processresponse to ischemia
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004708molecular_functionMAP kinase kinase activity
A0004713molecular_functionprotein tyrosine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0006468biological_processprotein phosphorylation
A0006915biological_processapoptotic process
A0007165biological_processsignal transduction
A0009410biological_processresponse to xenobiotic stimulus
A0019901molecular_functionprotein kinase binding
A0022602biological_processovulation cycle process
A0031098biological_processstress-activated protein kinase signaling cascade
A0032308biological_processpositive regulation of prostaglandin secretion
A0035872biological_processnucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
A0038066biological_processp38MAPK cascade
A0042770biological_processsignal transduction in response to DNA damage
A0043065biological_processpositive regulation of apoptotic process
A0043410biological_processpositive regulation of MAPK cascade
A0051403biological_processstress-activated MAPK cascade
A0051726biological_processregulation of cell cycle
A0051770biological_processpositive regulation of nitric-oxide synthase biosynthetic process
A0060048biological_processcardiac muscle contraction
A0060348biological_processbone development
A0072709biological_processcellular response to sorbitol
A0090398biological_processcellular senescence
A0106310molecular_functionprotein serine kinase activity
A0120163biological_processnegative regulation of cold-induced thermogenesis
A1901796biological_processregulation of signal transduction by p53 class mediator
Functional Information from PDB Data
site_idAC1
Number of Residues19
DetailsBINDING SITE FOR RESIDUE ANK A 401
ChainResidue
AGLY60
ASER135
ALYS138
AASP179
ALYS181
ASER183
AASN184
AASP197
ASER201
ALYS210
AMG402
AALA63
ATYR64
AVAL67
AALA80
ALYS82
AMET129
AGLU130
AMET132

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG A 402
ChainResidue
AASN184
AASP197
AANK401

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGAYGVVEkMrhvpsgqi..........MAVK
ChainResidueDetails
ALEU59-LYS82

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ViHrDVKpsNVLI
ChainResidueDetails
AVAL175-ILE187

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
ChainResidueDetails
AASP179

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
ALEU59
ALYS82

site_idSWS_FT_FI3
Number of Residues1
DetailsSITE: Cleavage; by anthrax lethal factor
ChainResidueDetails
ALYS14

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine; by MAP3K; alternate => ECO:0000269|PubMed:16728640
ChainResidueDetails
ASER207

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by MAP3K; alternate => ECO:0000269|PubMed:16728640
ChainResidueDetails
ATHR211

222036

PDB entries from 2024-07-03

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