3VBG
Structure of hDM2 with Dimer Inducing Indolyl Hydantoin RO-2443
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | E3 ubiquitin-protein ligase Mdm2 | polymer | 85 | 10060.8 | 4 | UniProt (Q00987) Pfam (PF02201) | Homo sapiens (human) | Double minute 2 protein, Hdm2, Oncoprotein Mdm2, p53-binding protein Mdm2 |
| 2 | E, F, G, H (A, B, C, D) | (5Z)-5-[(6-chloro-7-methyl-1H-indol-3-yl)methylidene]-3-(3,4-difluorobenzyl)imidazolidine-2,4-dione | non-polymer | 401.8 | 4 | Chemie (03M) | |||
| 3 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 19 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 25 - 109 (UniProt: Q00987)
| PDB | External Database | Details |
|---|---|---|
| Glu 33 | Leu 33 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 40243.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1607.2 | |
| All* | Total formula weight | 41850.6 |
