3VAF

Structure of U2AF65 variant with BrU3 DNA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Splicing factor U2AF 65 kDa subunit	polymer	174	19075.8	2	UniProt (P26368) Pfam (PF00076) In PDB	Homo sapiens (human)	U2 auxiliary factor 65 kDa subunit, hU2AF(65), hU2AF65, U2 snRNP auxiliary factor large subunit
2	P, E	DNA 5'-D(*UP*UP*(BRU)P*(BRU)P*UP*UP*U)-3'	polymer	7	2144.0	2
3	A, B	1,4-DIETHYLENE DIOXIDE	non-polymer		88.1	4	Chemie (DIO)
4	A, B, P	SULFATE ION	non-polymer		96.1	6	Chemie (SO4)
5	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
6	B	N,N-BIS(3-D-GLUCONAMIDOPROPYL)DEOXYCHOLAMIDE	non-polymer		862.1	1	Chemie (CPQ)
7		water	water		18.0	119	Chemie (HOH)

Sequence modifications

A, B: 148 - 237 (UniProt: P26368)

PDB	External Database	Details
Gly 143	-	expression tag
Pro 144	-	expression tag
Leu 145	-	expression tag
Gly 146	-	expression tag
Ser 147	-	expression tag

A, B: 258 - 336 (UniProt: P26368)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	42439.5
Non-Polymers*	Number of molecules	12
	Total formula weight	1882.9
All*	Total formula weight	44322.5

*Water molecules are not included.