3V9H

Crystal structure of human 1-pyrroline-5-carboxylate dehydrogenase mutant S352A

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial	polymer	566	62003.2	4	UniProt (P30038) Pfam (PF00171)	Homo sapiens (human)	1-pyrroline-5-carboxylate dehydrogenase, P5C dehydrogenase, Aldehyde dehydrogenase family 4 member A1
2	E, F, G, H, I... (A, B, C, D)	SULFATE ION	non-polymer		96.1	7	Chemie (SO4)
3	L, M, N, O (A, B, C, D)	water	water		18.0	167	Chemie (HOH)

Sequence modifications

A, B, C, D: 18 - 563 (UniProt: P30038)

PDB	External Database	Details
Met -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag
Ser 1	-	expression tag
His 2	-	expression tag
His 3	-	expression tag
His 4	-	expression tag
His 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
Ser 8	-	expression tag
Ser 9	-	expression tag
Gly 10	-	expression tag
Leu 11	-	expression tag
Val 12	-	expression tag
Pro 13	-	expression tag
Arg 14	-	expression tag
Gly 15	-	expression tag
Ser 16	-	expression tag
His 17	-	expression tag
Ala 352	Ser 352	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	248012.8
Non-Polymers*	Number of molecules	7
	Total formula weight	672.4
All*	Total formula weight	248685.2

*Water molecules are not included.