3V8D
Crystal structure of human CYP7A1 in complex with 7-ketocholesterol
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Cholesterol 7-alpha-monooxygenase | polymer | 491 | 56481.8 | 2 | UniProt (P22680) Pfam (PF00067) | Homo sapiens (human) | CYPVII, Cholesterol 7-alpha-hydroxylase, Cytochrome P450 7A1 |
| 2 | C, M (A, B) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 2 | Chemie (HEM) | |||
| 3 | D, N (A, B) | (3beta,8alpha,9beta)-3-hydroxycholest-5-en-7-one | non-polymer | 400.6 | 2 | Chemie (0GV) PubChem (22833527) PubChem (24212189) PubChem (25749206) PubChem (40477503) PubChem (40477504) PubChem (40507267) PubChem (16758056) PubChem (91474) PubChem (46782013) PubChem (50990351) PubChem (53477696) PubChem (59884222) PubChem (59890142) PubChem (59965214) PubChem (70954122) PubChem (73603932) PubChem (287664) PubChem (91746649) PubChem (124301250) PubChem (125027674) PubChem (10408716) PubChem (6710672) PubChem (99571088) PubChem (10179138) PubChem (12791165) PubChem (12791166) PubChem (12791167) PubChem (15955968) PubChem (125027673) PubChem (125027675) PubChem (170210882) PubChem (126968900) PubChem (132082433) PubChem (156133234) PubChem (162936028) PubChem (162936029) | |||
| 4 | E, F, G, O, P... (A, B) | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 5 | H, I, J, K, L... (A, B) | UNKNOWN ATOM OR ION | non-polymer | 14 | Chemie (UNX) | ||||
| 6 | AA, BA (A, B) | water | water | 18.0 | 354 | Chemie (HOH) |
Sequence modifications
A, B: 25 - 503 (UniProt: P22680)
| PDB | External Database | Details |
|---|---|---|
| Met 18 | - | expression tag |
| Ala 19 | - | expression tag |
| Lys 20 | - | expression tag |
| Lys 21 | - | expression tag |
| Thr 22 | - | expression tag |
| Ser 23 | - | expression tag |
| Ser 24 | - | expression tag |
| Leu 104 | Thr 104 | engineered mutation |
| His 504 | - | expression tag |
| His 505 | - | expression tag |
| His 506 | - | expression tag |
| His 507 | - | expression tag |
| His 508 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 112963.7 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 2610.6 | |
| All* | Total formula weight | 115574.3 |
