3V3O
Crystal structure of TetX2 T280A: an adaptive mutant in complex with tigecycline
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | TetX2 protein | polymer | 378 | 42502.1 | 4 | UniProt (Q93L51) Pfam (PF01494) | Bacteroides thetaiotaomicron | |
| 2 | E, F, I, J, L... (A, B) | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 3 | G, K, P, R (A, B, C, D) | FLAVIN-ADENINE DINUCLEOTIDE | non-polymer | 785.5 | 4 | Chemie (FAD) | |||
| 4 | H, M, O, Q (A, B, C, D) | TIGECYCLINE | non-polymer | 587.7 | 4 | Chemie (T1C) | |||
| 5 | S, T, U, V (A, B, C, D) | water | water | 18.0 | 23 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 11 - 388 (UniProt: Q93L51)
| PDB | External Database | Details |
|---|---|---|
| Lys 94 | Glu 94 | engineered mutation |
| Lys 266 | Glu 266 | engineered mutation |
| Ala 280 | Thr 280 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 170008.6 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 6069.2 | |
| All* | Total formula weight | 176077.8 |
