Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3V3O

Crystal structure of TetX2 T280A: an adaptive mutant in complex with tigecycline

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004497	molecular_function	monooxygenase activity
A	0005737	cellular_component	cytoplasm
A	0016491	molecular_function	oxidoreductase activity
A	0046677	biological_process	response to antibiotic
A	0071949	molecular_function	FAD binding
B	0000166	molecular_function	nucleotide binding
B	0004497	molecular_function	monooxygenase activity
B	0005737	cellular_component	cytoplasm
B	0016491	molecular_function	oxidoreductase activity
B	0046677	biological_process	response to antibiotic
B	0071949	molecular_function	FAD binding
C	0000166	molecular_function	nucleotide binding
C	0004497	molecular_function	monooxygenase activity
C	0005737	cellular_component	cytoplasm
C	0016491	molecular_function	oxidoreductase activity
C	0046677	biological_process	response to antibiotic
C	0071949	molecular_function	FAD binding
D	0000166	molecular_function	nucleotide binding
D	0004497	molecular_function	monooxygenase activity
D	0005737	cellular_component	cytoplasm
D	0016491	molecular_function	oxidoreductase activity
D	0046677	biological_process	response to antibiotic
D	0071949	molecular_function	FAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 401

Chain	Residue
A	ARG137
A	LYS156

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 402

Chain	Residue
A	LYS72
A	GLY75
A	LEU76
A	LEU77
A	GLN78

site_id	AC3
Number of Residues	27
Details	BINDING SITE FOR RESIDUE FAD A 403

Chain	Residue
A	GLY25
A	PRO26
A	VAL27
A	TYR45
A	GLU46
A	ARG47
A	ASP48
A	LEU60
A	ASP61
A	ARG117
A	ARG137
A	LEU139
A	ASN168
A	GLY169
A	GLN192
A	GLY310
A	ASP311
A	PRO318
A	GLY321
A	GLN322
A	GLY323
A	VAL324
A	ASN325
A	T1C404
A	HOH502
A	GLY23
A	GLY24

site_id	AC4
Number of Residues	16
Details	BINDING SITE FOR RESIDUE T1C A 404

Chain	Residue
A	THR59
A	GLU114
A	GLN192
A	ARG213
A	PHE224
A	ASN226
A	GLY236
A	PRO318
A	PHE319
A	ALA320
A	GLY321
A	ASN371
A	MET375
A	PHE382
A	GLN383
A	FAD403

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 401

Chain	Residue
B	GLU52
B	ARG54
D	ARG54

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 402

Chain	Residue
B	ARG51
B	LEU125
B	ASP131
B	THR132
B	VAL133
B	TRP135

site_id	AC7
Number of Residues	28
Details	BINDING SITE FOR RESIDUE FAD B 403

Chain	Residue
B	GLY23
B	GLY24
B	GLY25
B	PRO26
B	VAL27
B	TYR45
B	GLU46
B	ARG47
B	ASP48
B	LEU60
B	ASP61
B	ARG117
B	ARG137
B	LEU139
B	ALA167
B	ASN168
B	GLY169
B	GLN192
B	LEU287
B	GLY310
B	ASP311
B	PRO318
B	GLY321
B	GLN322
B	GLY323
B	VAL324
B	T1C405
B	HOH502

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 404

Chain	Residue
B	ARG54
D	GLU52
D	ARG54

site_id	AC9
Number of Residues	13
Details	BINDING SITE FOR RESIDUE T1C B 405

Chain	Residue
B	GLU367
B	MET375
B	PHE382
B	FAD403
B	GLN192
B	ARG213
B	PHE224
B	HIS234
B	GLY236
B	PRO318
B	PHE319
B	ALA320
B	GLY321

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 406

Chain	Residue
B	ARG137
B	LYS156

site_id	BC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE T1C C 401

Chain	Residue
C	ASN190
C	GLN192
C	ARG213
C	PHE224
C	ALA225
C	HIS234
C	GLY236
C	PRO318
C	PHE319
C	GLY321
C	MET375
C	FAD402

site_id	BC3
Number of Residues	27
Details	BINDING SITE FOR RESIDUE FAD C 402

Chain	Residue
C	GLY23
C	GLY24
C	GLY25
C	PRO26
C	VAL27
C	TYR45
C	GLU46
C	ARG47
C	THR59
C	ASP61
C	ARG117
C	ARG137
C	LYS138
C	LEU139
C	ALA167
C	ASN168
C	GLY169
C	GLN192
C	GLY310
C	ASP311
C	PRO318
C	GLY321
C	GLN322
C	GLY323
C	VAL324
C	ASN325
C	T1C401

site_id	BC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE T1C D 401

Chain	Residue
D	HIS63
D	GLN192
D	ARG213
D	PHE224
D	ALA225
D	ASN226
D	HIS234
D	PRO318
D	PHE319
D	ALA320
D	GLY321
D	PHE382
D	FAD402

site_id	BC5
Number of Residues	23
Details	BINDING SITE FOR RESIDUE FAD D 402

Chain	Residue
D	GLY23
D	GLY25
D	PRO26
D	VAL27
D	GLU46
D	ARG47
D	ASP61
D	ARG117
D	ARG137
D	LYS138
D	LEU139
D	ASN168
D	GLY169
D	GLN192
D	GLY310
D	ASP311
D	PRO318
D	GLY321
D	GLN322
D	GLY323
D	VAL324
D	ASN325
D	T1C401

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21402075","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21590745","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2XDO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XYO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2Y6Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2Y6R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P9U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3V3N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3V3O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4A6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4A99","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GUV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00845","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21402075","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00845","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"3V3O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00845","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21402075","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21590745","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2XDO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XYO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2Y6Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2Y6R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P9U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3V3N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3V3O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4A6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4A99","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GUV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21402075","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23999299","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2Y6Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2Y6R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3V3N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4A99","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21402075","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23999299","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2Y6Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2Y6R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3V3O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4A6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4A99","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)