3UW5

Crystal structure of the BIR domain of MLIAP bound to GDC0152

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Baculoviral IAP repeat-containing protein 7, Baculoviral IAP repeat-containing protein 4	polymer	116	13072.5	2	UniProt (Q96CA5) UniProt (P98170) Pfam (PF00653)	Homo sapiens (human)	Kidney inhibitor of apoptosis protein, KIAP, Livin, Melanoma inhibitor of apoptosis protein, ML-IAP, RING finger protein 50, E3 ubiquitin-protein ligase XIAP, IAP-like protein, ILP, hILP, Inhibitor of apoptosis protein 3, IAP-3, hIAP-3, hIAP3, X-linked inhibitor of apoptosis protein, X-linked IAP
2	C, D (Z, Y)	GDC-0152	polymer	4	498.6	2	BIRD (PRD_001020)
3	E, G (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
4	F, H (A, B)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
5	I, J, K, L (A, B, Z, Y)	water	water		18.0	189	Chemie (HOH)

Sequence modifications

A, B: 63 - 159 (UniProt: Q96CA5)

PDB	External Database	Details
Gly 57	-	EXPRESSION TAG
Ser 58	-	EXPRESSION TAG
His 59	-	EXPRESSION TAG
Met 60	-	EXPRESSION TAG
Leu 61	-	EXPRESSION TAG
Glu 62	-	EXPRESSION TAG
Gly 150	Ser 150	ENGINEERED MUTATION

A, B: 160 - 172 (UniProt: P98170)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	27142.3
Non-Polymers*	Number of molecules	4
	Total formula weight	322.9
All*	Total formula weight	27465.3

*Water molecules are not included.