3UPQ
Crystal structure of the pre-catalytic ternary complex of polymerase lambda with an rATP analog opposite a templating T.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA polymerase lambda | polymer | 329 | 36736.0 | 1 | UniProt (Q9UGP5) Pfam (PF14716) Pfam (PF10391) Pfam (PF14792) Pfam (PF14791) | Homo sapiens (human) | Pol Lambda, DNA polymerase beta-2, Pol beta2, DNA polymerase kappa |
| 2 | B (T) | 5'-D(*CP*GP*GP*CP*TP*GP*TP*AP*CP*TP*G)-3' | polymer | 11 | 3365.2 | 1 | |||
| 3 | C (P) | 5'-D(*CP*AP*GP*TP*AP*C)-3' | polymer | 6 | 1793.2 | 1 | |||
| 4 | D (D) | 5'-D(P*GP*CP*CP*G)-3' | polymer | 4 | 1191.8 | 1 | |||
| 5 | E (A) | 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine | non-polymer | 506.2 | 1 | Chemie (ZAN) | |||
| 6 | F, G, H (A) | MANGANESE (II) ION | non-polymer | 54.9 | 3 | Chemie (MN) | |||
| 7 | I (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 8 | J, K, L, M (A) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 9 | N, O, P, Q (A, T, P, D) | water | water | 18.0 | 255 | Chemie (HOH) |
Sequence modifications
A: 242 - 575 (UniProt: Q9UGP5)
| PDB | External Database | Details |
|---|---|---|
| Lys 463 | Ser 463 | SEE REMARK 999 |
| Gly 464 | Gln 464 | SEE REMARK 999 |
| Glu 470 | Gln 470 | SEE REMARK 999 |
| Thr 471 | Gln 471 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 43086.3 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1078.3 | |
| All* | Total formula weight | 44164.5 |
