3UPQ

Crystal structure of the pre-catalytic ternary complex of polymerase lambda with an rATP analog opposite a templating T.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0006281	biological_process	DNA repair
A	0016779	molecular_function	nucleotidyltransferase activity
A	0034061	molecular_function	DNA polymerase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	26
Details	BINDING SITE FOR RESIDUE ZAN A 0

Chain	Residue
A	MN1
A	ARG386
A	GLY416
A	SER417
A	ARG420
A	CYS425
A	GLY426
A	ASP427
A	ASP429
A	TYR505
A	PHE506
A	MN2
A	THR507
A	GLY508
A	ALA510
A	ASN513
P	DC6
P	HOH212
T	DT5
A	HOH52
A	HOH207
A	HOH208
A	HOH209
A	HOH211
A	HOH213
A	HOH223

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN A 1

Chain	Residue
A	ZAN0
A	MN2
A	HOH215
A	ASP427
A	ASP429

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MN A 2

Chain	Residue
A	ZAN0
A	MN1
A	HOH213
A	ASP427
A	ASP429
A	ASP490
P	DC6

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN A 3

Chain	Residue
A	HOH195
A	HOH196
A	HOH197
A	HOH198
A	ASP382
A	HIS486

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 4

Chain	Residue
A	SER339
A	ILE341
A	ALA344
A	HOH578
P	DA5
P	HOH50

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 5

Chain	Residue
A	HOH15
A	GLY442
A	ILE443
A	PHE444
A	SER445

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 6

Chain	Residue
A	HOH116
A	HIS440
A	ARG441

---

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 7

Chain	Residue
A	LYS273
A	TRP274

---

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 8

Chain	Residue
A	HOH104
A	ARG419

---

Functional Information from PROSITE/UniProt

site_id	PS00522
Number of Residues	20
Details	DNA_POLYMERASE_X DNA polymerase family X signature. GSYrRGkatCgDVDVLIthP

Chain	Residue	Details
A	GLY416-PRO435

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Schiff-base intermediate with DNA => ECO:0000269|PubMed:11457865

Chain	Residue	Details
A	LYS312

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ

Chain	Residue	Details
A	ARG386
A	SER417
A	GLY426
A	ALA518

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ

Chain	Residue	Details
A	ASP427
A	ASP429
A	PRO495

---