3UON
Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Human M2 muscarinic acetylcholine, receptor T4 lysozyme fusion protein | polymer | 467 | 52694.5 | 1 | UniProt (P08172) UniProt (P00720) Pfam (PF00001) Pfam (PF00959) | Homo sapiens | |
| 2 | B (A) | (3R)-1-azabicyclo[2.2.2]oct-3-yl hydroxy(diphenyl)acetate | non-polymer | 337.4 | 1 | Chemie (QNB) | |||
| 3 | C (A) | beta-D-glucopyranose | non-polymer | 180.2 | 1 | Chemie (BGC) | |||
| 4 | D, E (A) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 5 | F (A) | water | water | 18.0 | 57 | Chemie (HOH) |
Sequence modifications
A: 1 - 217 (UniProt: P08172)
A: 1002 - 1161 (UniProt: P00720)
A: 377 - 466 (UniProt: P08172)
| PDB | External Database | Details |
|---|---|---|
| Asp 2 | Asn 2 | engineered mutation |
| Asp 3 | Asn 3 | engineered mutation |
| Asp 6 | Asn 6 | engineered mutation |
| Asp 9 | Asn 9 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Thr 1054 | Cys 54 | engineered mutation |
| Ala 1097 | Cys 97 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 52694.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 588.5 | |
| All* | Total formula weight | 53283.0 |
