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3UM8

Wild-type Plasmodium falciparum DHFR-TS complexed with cycloguanil and NADPH

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
Bifunctional dihydrofolate reductase-thymidylate synthasepolymer60871828.02UniProt (A7UD81)
Pfam (PF00186)
Pfam (PF00303)
Plasmodium falciparumDHFR-TS
2C, G
(A, B)
1-(4-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diaminenon-polymer251.72Chemie (1CY)
3D, H
(A, B)
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATEnon-polymer745.42Chemie (NDP)
4E, F
(A)
PHOSPHATE IONnon-polymer95.02Chemie (PO4)
5I, J
(A, B)
waterwater18.0456Chemie (HOH)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight143656.0
Non-Polymers*Number of molecules6
Total formula weight2184.2
All*Total formula weight145840.2
*Water molecules are not included.

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PDB entries from 2025-07-23

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