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3UM8

Wild-type Plasmodium falciparum DHFR-TS complexed with cycloguanil and NADPH

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0003824molecular_functioncatalytic activity
A0004146molecular_functiondihydrofolate reductase activity
A0004799molecular_functionthymidylate synthase activity
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0006231biological_processdTMP biosynthetic process
A0006730biological_processone-carbon metabolic process
A0008152biological_processmetabolic process
A0008168molecular_functionmethyltransferase activity
A0009165biological_processnucleotide biosynthetic process
A0016491molecular_functionoxidoreductase activity
A0016740molecular_functiontransferase activity
A0016741molecular_functiontransferase activity, transferring one-carbon groups
A0032259biological_processmethylation
A0046654biological_processtetrahydrofolate biosynthetic process
B0000166molecular_functionnucleotide binding
B0003824molecular_functioncatalytic activity
B0004146molecular_functiondihydrofolate reductase activity
B0004799molecular_functionthymidylate synthase activity
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0006231biological_processdTMP biosynthetic process
B0006730biological_processone-carbon metabolic process
B0008152biological_processmetabolic process
B0008168molecular_functionmethyltransferase activity
B0009165biological_processnucleotide biosynthetic process
B0016491molecular_functionoxidoreductase activity
B0016740molecular_functiontransferase activity
B0016741molecular_functiontransferase activity, transferring one-carbon groups
B0032259biological_processmethylation
B0046654biological_processtetrahydrofolate biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues10
DetailsBINDING SITE FOR RESIDUE 1CY A 609
ChainResidue
AILE14
ANDP610
ACYS15
AASP54
APHE58
ASER108
AILE112
AILE164
ATYR170
ATHR185

site_idAC2
Number of Residues27
DetailsBINDING SITE FOR RESIDUE NDP A 610
ChainResidue
ACYS15
AALA16
ALEU40
AGLY41
AASN42
AGLY44
AVAL45
ALEU46
AGLY105
AARG106
ATHR107
ASER108
ALEU127
ASER128
AARG129
ATHR130
AASN144
AILE164
AGLY165
AGLY166
ASER167
AVAL168
AVAL169
ATYR170
AGLU172
A1CY609
AHOH1365

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE PO4 A 801
ChainResidue
AARG510
ASER511
AHOH1303
BARG470
BARG471
BHOH1007

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE PO4 A 802
ChainResidue
AARG470
AARG471
AHOH1083
BARG510
BSER511

site_idAC5
Number of Residues12
DetailsBINDING SITE FOR RESIDUE 1CY B 709
ChainResidue
BILE14
BCYS15
BALA16
BASP54
BPHE58
BSER108
BSER111
BILE112
BILE164
BTYR170
BTHR185
BNDP710

site_idAC6
Number of Residues25
DetailsBINDING SITE FOR RESIDUE NDP B 710
ChainResidue
BCYS15
BALA16
BLEU40
BGLY44
BVAL45
BLEU46
BGLY105
BARG106
BTHR107
BSER108
BLEU127
BSER128
BARG129
BTHR130
BASN144
BILE164
BGLY165
BGLY166
BSER167
BVAL168
BVAL169
BTYR170
BGLU172
BVAL195
B1CY709

Functional Information from PROSITE/UniProt
site_idPS00075
Number of Residues24
DetailsDHFR_1 Dihydrofolate reductase (DHFR) domain signature. GLGnkgvLPWkcnslDmkyFcavT
ChainResidueDetails
AGLY39-THR62

site_idPS00091
Number of Residues29
DetailsTHYMIDYLATE_SYNTHASE Thymidylate synthase active site. RriLlcaWNvkdldqma.....LpPCHilcQFyV
ChainResidueDetails
AARG470-VAL498

218853

PDB entries from 2024-04-24

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