3UIU

Crystal structure of Apo-PKR kinase domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Interferon-induced, double-stranded RNA-activated protein kinase	polymer	306	35568.5	2	UniProt (P19525) Pfam (PF00069)	Homo sapiens (human)	Eukaryotic translation initiation factor 2-alpha kinase 2, eIF-2A protein kinase 2, Interferon-inducible RNA-dependent protein kinase, P1/eIF-2A protein kinase, Protein kinase RNA-activated, PKR, Tyrosine-protein kinase EIF2AK2, p68 kinase
2	C, D (A, B)	water	water		18.0	24	Chemie (HOH)

Sequence modifications

A, B: 254 - 551 (UniProt: P19525)

PDB	External Database	Details
Arg 296	Lys 296	SEE REMARK 999
Val 552	-	expression tag
Leu 553	-	expression tag
His 554	-	expression tag
His 555	-	expression tag
His 556	-	expression tag
His 557	-	expression tag
His 558	-	expression tag
His 559	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	71137.0
All*	Total formula weight	71137.0

*Water molecules are not included.