3UIU
Crystal structure of Apo-PKR kinase domain
Functional Information from GO Data
Functional Information from PROSITE/UniProt
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. LiHrDLKpsNIFL |
| Chain | Residue | Details |
| A | LEU410-LEU422 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 |
| Chain | Residue | Details |
| A | ASP414 | |
| B | ASP414 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 |
| Chain | Residue | Details |
| A | ILE273 | |
| B | ILE273 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ARG296 | |
| B | ARG296 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:16179258, ECO:0000305|PubMed:31246429 |
| Chain | Residue | Details |
| A | ASP432 | |
| B | ASP432 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphothreonine; by autocatalysis => ECO:0000305|PubMed:11152499 |
| Chain | Residue | Details |
| A | THR255 | |
| A | THR258 | |
| B | THR255 | |
| B | THR258 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:16373505 |
| Chain | Residue | Details |
| A | TYR293 | |
| B | TYR293 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:11337501, ECO:0000269|PubMed:16179258 |
| Chain | Residue | Details |
| A | THR446 | |
| B | THR446 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:11337501, ECO:0000269|PubMed:20685959 |
| Chain | Residue | Details |
| A | THR451 | |
| B | THR451 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648 |
| Chain | Residue | Details |
| A | SER456 | |
| B | SER456 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER542 | |
| B | SER542 |
