3U7Y
Structure of NIH45-46 Fab in complex with gp120 of 93TH057 HIV
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (H) | NIH45-46 heavy chain, Ig gamma-1 chain C region | polymer | 229 | 25089.3 | 1 | UniProt (P01857) Pfam (PF07654) | Homo sapiens (human) | |
| 2 | B (G) | Envelope glycoprotein gp160 | polymer | 361 | 40204.5 | 1 | UniProt (Q0ED31) Pfam (PF00516) UniProt (by SIFTS) (A0A0M3KKW9) | Human immunodeficiency virus 1 | |
| 3 | C (L) | NIH45-46 light chain, Ig kappa chain C region | polymer | 210 | 23000.4 | 1 | UniProt (P01834) Pfam (PF07654) | Homo sapiens (human) | |
| 4 | D (A) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G81315DD) | |||
| 5 | E (H) | CITRATE ANION | non-polymer | 189.1 | 1 | Chemie (FLC) | |||
| 6 | F, G, H, J, K... (G, L) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) | |||
| 7 | I (G) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 8 | M, N, O (H, G, L) | water | water | 18.0 | 67 | Chemie (HOH) |
Sequence modifications
H: 1 - 117 (PDB: 3U7Y)
H: 118 - 221 (UniProt: P01857)
G: 44 - 123 (UniProt: Q0ED31)
G: 199 - 301 (UniProt: Q0ED31)
G: 324 - 492 (UniProt: Q0ED31)
L: 1 - 104 (PDB: 3U7Y)
L: 105 - 210 (UniProt: P01834)
H: 118 - 221 (UniProt: P01857)
G: 44 - 123 (UniProt: Q0ED31)
| PDB | External Database | Details |
|---|---|---|
| Cys 65 | Val 64 | engineered mutation |
| Cys 115 | Ser 114 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 124 | - | linker |
| Gly 198 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Gly 318 | - | linker |
| Gly 319 | - | linker |
| Ser 320 | - | linker |
| Gly 321 | - | linker |
| Ser 322 | - | linker |
| Gly 323 | - | linker |
| Gly 493 | - | expression tag |
| Ser 494 | - | expression tag |
| His 495 | - | expression tag |
| His 496 | - | expression tag |
| His 497 | - | expression tag |
| His 498 | - | expression tag |
| His 499 | - | expression tag |
| His 500 | - | expression tag |
L: 105 - 210 (UniProt: P01834)
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 88294.3 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 748.7 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1551.8 | |
| All* | Total formula weight | 90594.8 |
