3U1N

Structure of the catalytic core of human SAMHD1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	SAM domain and HD domain-containing protein 1	polymer	528	61521.6	4	UniProt (Q9Y3Z3) Pfam (PF01966)	Homo sapiens (human)	Dendritic cell-derived IFNG-induced protein, DCIP, Monocyte protein 5, MOP-5
2	E, G, I, K (A, B, C, D)	PHOSPHATE ION	non-polymer		95.0	4	Chemie (PO4)
3	F, H, J, L (A, B, C, D)	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
4	M, N, O, P (A, B, C, D)	water	water		18.0	28	Chemie (HOH)

Sequence modifications

A, B, C, D: 120 - 626 (UniProt: Q9Y3Z3)

PDB	External Database	Details
Ala 99	-	expression tag
Ser 100	-	expression tag
Trp 101	-	expression tag
Ser 102	-	expression tag
His 103	-	expression tag
Pro 104	-	expression tag
Gln 105	-	expression tag
Phe 106	-	expression tag
Glu 107	-	expression tag
Lys 108	-	expression tag
Gly 109	-	expression tag
Ala 110	-	expression tag
Leu 111	-	expression tag
Glu 112	-	expression tag
Val 113	-	expression tag
Leu 114	-	expression tag
Phe 115	-	expression tag
Gln 116	-	expression tag
Gly 117	-	expression tag
Pro 118	-	expression tag
Gly 119	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	246086.5
Non-Polymers*	Number of molecules	8
	Total formula weight	641.5
All*	Total formula weight	246728.0

*Water molecules are not included.