3U11
Tetramerization dynamics of the C-terminus underlies isoform-specific cAMP-gating in HCN channels
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | polymer | 210 | 24626.1 | 2 | UniProt (Q9Y3Q4) Pfam (PF00027) | Homo sapiens (human) | |
| 2 | C, I (A, B) | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE | non-polymer | 329.2 | 2 | Chemie (CMP) | |||
| 3 | D, E, F, G, H (A) | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
| 4 | J, K (A, B) | water | water | 18.0 | 147 | Chemie (HOH) |
Sequence modifications
A, B: 521 - 723 (UniProt: Q9Y3Q4)
| PDB | External Database | Details |
|---|---|---|
| Gln 514 | - | expression tag |
| Gly 515 | - | expression tag |
| Pro 516 | - | expression tag |
| Ser 517 | - | expression tag |
| Ser 518 | - | expression tag |
| Pro 519 | - | expression tag |
| Met 520 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 49252.3 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1118.9 | |
| All* | Total formula weight | 50371.1 |
