3U11
Tetramerization dynamics of the C-terminus underlies isoform-specific cAMP-gating in HCN channels
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | polymer | 210 | 24626.1 | 2 | UniProt (Q9Y3Q4) Pfam (PF00027) | Homo sapiens (human) | |
| 2 | C, I (A, B) | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE | non-polymer | 329.2 | 2 | Chemie (CMP) PubChem (176488666) PubChem (6076) PubChem (23902375) PubChem (25322948) PubChem (40467852) PubChem (44629928) PubChem (25322946) PubChem (56973690) PubChem (216878) PubChem (59909322) PubChem (59968988) PubChem (70878457) PubChem (59350541) PubChem (3080770) PubChem (3246347) PubChem (274) PubChem (6604194) PubChem (6603718) PubChem (6713792) PubChem (6714006) PubChem (124132380) PubChem (12071879) PubChem (12866365) PubChem (163043517) PubChem (129317551) PubChem (131841987) PubChem (134693155) PubChem (138107790) PubChem (163043518) | |||
| 3 | D, E, F, G, H (A) | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) PubChem (753) | |||
| 4 | J, K (A, B) | water | water | 18.0 | 147 | Chemie (HOH) |
Sequence modifications
A, B: 521 - 723 (UniProt: Q9Y3Q4)
| PDB | External Database | Details |
|---|---|---|
| Gln 514 | - | expression tag |
| Gly 515 | - | expression tag |
| Pro 516 | - | expression tag |
| Ser 517 | - | expression tag |
| Ser 518 | - | expression tag |
| Pro 519 | - | expression tag |
| Met 520 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 49252.3 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1118.9 | |
| All* | Total formula weight | 50371.1 |
