3U11
Tetramerization dynamics of the C-terminus underlies isoform-specific cAMP-gating in HCN channels
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE CMP A 846 |
| Chain | Residue |
| A | GLU649 |
| A | ALA671 |
| A | ARG710 |
| A | ARG713 |
| A | THR650 |
| A | PHE658 |
| A | GLY659 |
| A | GLU660 |
| A | ILE661 |
| A | CYS662 |
| A | ARG669 |
| A | THR670 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 724 |
| Chain | Residue |
| A | LEU543 |
| A | PRO544 |
| A | PRO545 |
| A | ARG548 |
| B | PRO594 |
| B | LEU595 |
| B | ALA599 |
| B | ASP600 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE GOL A 725 |
| Chain | Residue |
| A | LYS651 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 726 |
| Chain | Residue |
| A | ASN583 |
| A | PHE596 |
| A | ALA599 |
| A | PRO601 |
| A | VAL604 |
| A | THR605 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 727 |
| Chain | Residue |
| A | HOH149 |
| A | HOH157 |
| A | GLU625 |
| A | GLY626 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 728 |
| Chain | Residue |
| A | LEU652 |
| A | SER656 |
| A | ASP709 |
| A | ARG710 |
| A | ARG713 |
| site_id | AC7 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE CMP B 846 |
| Chain | Residue |
| B | VAL642 |
| B | THR650 |
| B | PHE658 |
| B | GLY659 |
| B | GLU660 |
| B | ILE661 |
| B | CYS662 |
| B | ARG669 |
| B | THR670 |
| B | ALA671 |
| B | ARG710 |
| B | ILE714 |
Functional Information from PROSITE/UniProt
| site_id | PS00888 |
| Number of Residues | 17 |
| Details | CNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. IIrEGTiGKkMYFIqhG |
| Chain | Residue | Details |
| A | ILE622-GLY638 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24776929","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4KL1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22006928","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23103389","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3U11","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HBN","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9TV66","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22006928","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3U11","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23103389","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4HBN","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
