3TWP

Crystal structure of M. tuberculosis TrpD in complex with an inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Anthranilate phosphoribosyltransferase	polymer	377	38717.7	4	UniProt (P66992) Pfam (PF02885) Pfam (PF00591) UniProt (by SIFTS) (P9WFX5) In PDB	Mycobacterium tuberculosis
2	A, B, C, D	1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose	non-polymer		390.1	4	Chemie (PRP)
3	A, B, C, D	MAGNESIUM ION	non-polymer		24.3	8	Chemie (MG)
4	A, B, C, D	2-HYDROXYBENZOIC ACID	non-polymer		138.1	4	Chemie (SAL)
5	B, C, D	GLYCEROL	non-polymer		92.1	3	Chemie (GOL)
6		water	water		18.0	1199	Chemie (HOH)

Sequence modifications

A, B, C, D: 2 - 370 (UniProt: P66992)

PDB	External Database	Details
Leu 371	-	expression tag
Glu 372	-	expression tag
His 373	-	expression tag
His 374	-	expression tag
His 375	-	expression tag
His 376	-	expression tag
His 377	-	expression tag
His 378	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	154870.8
Non-Polymers*	Number of molecules	19
	Total formula weight	2583.5
All*	Total formula weight	157454.2

*Water molecules are not included.