3TWP

Crystal structure of M. tuberculosis TrpD in complex with an inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000162	biological_process	tryptophan biosynthetic process
A	0000287	molecular_function	magnesium ion binding
A	0004048	molecular_function	anthranilate phosphoribosyltransferase activity
A	0005576	cellular_component	extracellular region
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0016757	molecular_function	glycosyltransferase activity
A	0016763	molecular_function	pentosyltransferase activity
A	0046872	molecular_function	metal ion binding
B	0000162	biological_process	tryptophan biosynthetic process
B	0000287	molecular_function	magnesium ion binding
B	0004048	molecular_function	anthranilate phosphoribosyltransferase activity
B	0005576	cellular_component	extracellular region
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0016757	molecular_function	glycosyltransferase activity
B	0016763	molecular_function	pentosyltransferase activity
B	0046872	molecular_function	metal ion binding
C	0000162	biological_process	tryptophan biosynthetic process
C	0000287	molecular_function	magnesium ion binding
C	0004048	molecular_function	anthranilate phosphoribosyltransferase activity
C	0005576	cellular_component	extracellular region
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0016757	molecular_function	glycosyltransferase activity
C	0016763	molecular_function	pentosyltransferase activity
C	0046872	molecular_function	metal ion binding
D	0000162	biological_process	tryptophan biosynthetic process
D	0000287	molecular_function	magnesium ion binding
D	0004048	molecular_function	anthranilate phosphoribosyltransferase activity
D	0005576	cellular_component	extracellular region
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0016757	molecular_function	glycosyltransferase activity
D	0016763	molecular_function	pentosyltransferase activity
D	0046872	molecular_function	metal ion binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00211

Chain	Residue	Details
A	GLY107
B	GLY107
C	GLY107
D	GLY107

---

site_id	SWS_FT_FI2
Number of Residues	32
Details	BINDING:

Chain	Residue	Details
A	GLY110
B	ASN117
B	SER119
B	LYS135
B	ASN138
B	ARG193
B	ASP251
B	GLU252
C	GLY110
C	ASN117
C	SER119
A	ASN117
C	LYS135
C	ASN138
C	ARG193
C	ASP251
C	GLU252
D	GLY110
D	ASN117
D	SER119
D	LYS135
D	ASN138
A	SER119
D	ARG193
D	ASP251
D	GLU252
A	LYS135
A	ASN138
A	ARG193
A	ASP251
A	GLU252
B	GLY110

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00211, ECO:0000269|PubMed:16337227, ECO:0000269|PubMed:23363292, ECO:0000269|Ref.4, ECO:0000269|Ref.5

Chain	Residue	Details
A	THR115
A	GLY147
B	THR115
B	GLY147
C	THR115
C	GLY147
D	THR115
D	GLY147

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: N-acetylalanine => ECO:0007744|PubMed:21969609

Chain	Residue	Details
A	ALA2
B	ALA2
C	ALA2
D	ALA2

---