3TUG
Crystal structure of the HECT domain of ITCH E3 ubiquitin ligase
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | E3 ubiquitin-protein ligase Itchy homolog | polymer | 398 | 47490.1 | 1 | UniProt (Q96J02) Pfam (PF00632) In PDB | Homo sapiens (human) | Itch, Atrophin-1-interacting protein 4, AIP4, NFE2-associated polypeptide 1, NAPP1 |
2 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
3 | A | UNKNOWN ATOM OR ION | non-polymer | 9 | Chemie (UNX) | ||||
4 | water | water | 18.0 | 78 | Chemie (HOH) |
Sequence modifications
A: 524 - 903 (UniProt: Q96J02)
PDB | External Database | Details |
---|---|---|
Met 506 | - | expression tag |
His 507 | - | expression tag |
His 508 | - | expression tag |
His 509 | - | expression tag |
His 510 | - | expression tag |
His 511 | - | expression tag |
His 512 | - | expression tag |
Ser 513 | - | expression tag |
Ser 514 | - | expression tag |
Gly 515 | - | expression tag |
Arg 516 | - | expression tag |
Glu 517 | - | expression tag |
Asn 518 | - | expression tag |
Leu 519 | - | expression tag |
Tyr 520 | - | expression tag |
Phe 521 | - | expression tag |
Gln 522 | - | expression tag |
Gly 523 | - | expression tag |
Ser 605 | Leu 605 | engineered mutation |
Arg 801 | His 801 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 47490.1 | |
Non-Polymers* | Number of molecules | 10 |
Total formula weight | 35.5 | |
All* | Total formula weight | 47525.6 |