3TT0
Co-structure of Fibroblast Growth Factor Receptor 1 kinase domain with 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (BGJ398)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Basic fibroblast growth factor receptor 1 | polymer | 382 | 44298.1 | 2 | UniProt (P11362) Pfam (PF07714) In PDB | Homo sapiens (human) | FGFR-1, bFGF-R-1, Fms-like tyrosine kinase 2, FLT-2, Proto-oncogene c-Fgr |
2 | A, B | 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-{[4-(4-ethylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)-1-methylurea | non-polymer | 560.5 | 2 | Chemie (07J) | |||
3 | A, B | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
4 | B | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
5 | water | water | 18.0 | 413 | Chemie (HOH) |
Sequence modifications
A, B: 456 - 765 (UniProt: P11362)
PDB | External Database | Details |
---|---|---|
Met 408 | - | expression tag |
Gly 409 | - | expression tag |
Tyr 410 | - | expression tag |
Tyr 411 | - | expression tag |
His 412 | - | expression tag |
His 413 | - | expression tag |
His 414 | - | expression tag |
His 415 | - | expression tag |
His 416 | - | expression tag |
His 417 | - | expression tag |
Asp 418 | - | expression tag |
Tyr 419 | - | expression tag |
Asp 420 | - | expression tag |
Ile 421 | - | expression tag |
Pro 422 | - | expression tag |
Thr 423 | - | expression tag |
Thr 424 | - | expression tag |
Glu 425 | - | expression tag |
Asn 426 | - | expression tag |
Leu 427 | - | expression tag |
Tyr 428 | - | expression tag |
Phe 429 | - | expression tag |
Asn 430 | - | expression tag |
Gly 431 | - | expression tag |
Met 432 | - | expression tag |
Gly 433 | - | expression tag |
Tyr 434 | - | expression tag |
Tyr 435 | - | expression tag |
His 436 | - | expression tag |
His 437 | - | expression tag |
His 438 | - | expression tag |
His 439 | - | expression tag |
His 440 | - | expression tag |
His 441 | - | expression tag |
Asp 442 | - | expression tag |
Tyr 443 | - | expression tag |
Asp 444 | - | expression tag |
Ile 445 | - | expression tag |
Pro 446 | - | expression tag |
Thr 447 | - | expression tag |
Thr 448 | - | expression tag |
Glu 449 | - | expression tag |
Asn 450 | - | expression tag |
Leu 451 | - | expression tag |
Tyr 452 | - | expression tag |
Phe 453 | - | expression tag |
Gln 454 | - | expression tag |
Gly 455 | - | expression tag |
Ala 488 | Cys 488 | conflict |
Ser 584 | Cys 584 | engineered mutation |
Met 766 | - | expression tag |
Gly 767 | - | expression tag |
Tyr 768 | - | expression tag |
Tyr 769 | - | expression tag |
His 770 | - | expression tag |
His 771 | - | expression tag |
His 772 | - | expression tag |
His 773 | - | expression tag |
His 774 | - | expression tag |
His 775 | - | expression tag |
Asp 776 | - | expression tag |
Tyr 777 | - | expression tag |
Asp 778 | - | expression tag |
Ile 779 | - | expression tag |
Pro 780 | - | expression tag |
Thr 781 | - | expression tag |
Thr 782 | - | expression tag |
Glu 783 | - | expression tag |
Asn 784 | - | expression tag |
Leu 785 | - | expression tag |
Tyr 786 | - | expression tag |
Phe 787 | - | expression tag |
Asn 788 | - | expression tag |
Gly 789 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 88596.3 | |
Non-Polymers* | Number of molecules | 9 |
Total formula weight | 1781.5 | |
All* | Total formula weight | 90377.8 |