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3TT0

Co-structure of Fibroblast Growth Factor Receptor 1 kinase domain with 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (BGJ398)

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0004713molecular_functionprotein tyrosine kinase activity
A0005007molecular_functionfibroblast growth factor receptor activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
B0004672molecular_functionprotein kinase activity
B0004713molecular_functionprotein tyrosine kinase activity
B0005007molecular_functionfibroblast growth factor receptor activity
B0005524molecular_functionATP binding
B0006468biological_processprotein phosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues17
DetailsBINDING SITE FOR RESIDUE 07J A 1
ChainResidue
AHOH258
AVAL561
AGLU562
ATYR563
AALA564
AGLY567
AGLU571
AALA640
AASP641
AHOH380
AVAL492
AALA512
ALYS514
AGLU531
AMET535
AILE545
AVAL559

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 790
ChainResidue
AHOH217
AARG570
AARG661
ALEU662
ATRP666

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 A 2
ChainResidue
AHOH224
AARG577
ASER584
AGLY698
ASER699
BHIS717

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 A 4
ChainResidue
AHOH229
ALYS721
ACYS725
AASN727
BLYS721
BASN724

site_idAC5
Number of Residues16
DetailsBINDING SITE FOR RESIDUE 07J B 1
ChainResidue
BHOH110
BHOH284
BHOH346
BLEU484
BVAL492
BALA512
BGLU531
BMET535
BVAL561
BGLU562
BALA564
BGLY567
BGLU571
BLEU630
BALA640
BASP641

site_idAC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 B 3
ChainResidue
AHIS589
BLYS542
BARG609

site_idAC7
Number of Residues3
DetailsBINDING SITE FOR RESIDUE GOL B 790
ChainResidue
BLYS566
BTYR572
BARG576

site_idAC8
Number of Residues3
DetailsBINDING SITE FOR RESIDUE GOL B 2
ChainResidue
BHIS541
BGLU612
BTYR613

site_idAC9
Number of Residues3
DetailsBINDING SITE FOR RESIDUE GOL B 791
ChainResidue
BARG577
BGLY698
BSER699

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues31
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGAFGQVVlAeaigldkdkpnrvtk...VAVK
ChainResidueDetails
ALEU484-LYS514

site_idPS00109
Number of Residues13
DetailsPROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. CIHrDLAARNVLV
ChainResidueDetails
ACYS619-VAL631

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028, ECO:0000269|PubMed:19224897
ChainResidueDetails
AASP623
BASP623

site_idSWS_FT_FI2
Number of Residues12
DetailsBINDING:
ChainResidueDetails
ALEU484
BASN568
BARG627
BASP641
ALYS514
AGLU562
AASN568
AARG627
AASP641
BLEU484
BLYS514
BGLU562

site_idSWS_FT_FI3
Number of Residues6
DetailsMOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:16507368, ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:8622701
ChainResidueDetails
ATYR463
ATYR583
ATYR585
BTYR463
BTYR583
BTYR585

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:16507368, ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:19665973, ECO:0000269|PubMed:8622701
ChainResidueDetails
ATYR653
ATYR654
BTYR653
BTYR654

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:8622701
ChainResidueDetails
ATYR730
BTYR730

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PDB entries from 2024-06-26

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