3TSO

Structure of the cancer associated Rab25 protein in complex with FIP2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Ras-related protein Rab-25	polymer	178	19931.6	2	UniProt (P57735) Pfam (PF00071)	Homo sapiens (human)	CATX-8
2	C, D (C, D)	Rab11 family-interacting protein 2	polymer	75	8839.0	2	UniProt (Q7L804) Pfam (PF09457)	Homo sapiens (human)	Rab11-FIP2, NRip11
3	E, L (A, B)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
4	F, M (A, B)	PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER	non-polymer		522.2	2	Chemie (GNP)
5	G, H, I, N, O (A, B)	GLYCEROL	non-polymer		92.1	5	Chemie (GOL)
6	J, K (A)	PHOSPHATE ION	non-polymer		95.0	2	Chemie (PO4)
7	P, Q, R, S (A, B, C, D)	water	water		18.0	208	Chemie (HOH)

Sequence modifications

A, B: 7 - 180 (UniProt: P57735)

PDB	External Database	Details
Gly 3	-	expression tag
Ser 4	-	expression tag
His 5	-	expression tag
Met 6	-	expression tag

C, D: 440 - 512 (UniProt: Q7L804)

PDB	External Database	Details
Ser 438	-	expression tag
Met 439	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	57541.2
Non-Polymers*	Number of molecules	11
	Total formula weight	1743.4
All*	Total formula weight	59284.6

*Water molecules are not included.