3TQ0

Crystal structure of Leishmania major dihydroorotate dehydrogenase in complex with fumarate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Dihydroorotate dehydrogenase	polymer	346	37340.7	2	UniProt (Q4QEW7) Pfam (PF01180)	Leishmania major
2	C, K (A, B)	FLAVIN MONONUCLEOTIDE	non-polymer		456.3	2	Chemie (FMN)
3	D, L (A, B)	FUMARIC ACID	non-polymer		116.1	2	Chemie (FUM)
4	E, M (A, B)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
5	F (A)	NICKEL (II) ION	non-polymer		58.7	1	Chemie (NI)
6	G, H, I, J (A)	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
7	N, O (A, B)	water	water		18.0	388	Chemie (HOH)

Sequence modifications

A, B: 1 - 312 (UniProt: Q4QEW7)

PDB	External Database	Details
Met -33	-	expression tag
Gly -32	-	expression tag
Ser -31	-	expression tag
Ser -30	-	expression tag
His -29	-	expression tag
His -28	-	expression tag
His -27	-	expression tag
His -26	-	expression tag
His -25	-	expression tag
His -24	-	expression tag
Ser -23	-	expression tag
Ser -22	-	expression tag
Gly -21	-	expression tag
Leu -20	-	expression tag
Val -19	-	expression tag
Pro -18	-	expression tag
Ala -17	-	expression tag
Gly -16	-	expression tag
Ser -15	-	expression tag
His -14	-	expression tag
Met -13	-	expression tag
Ala -12	-	expression tag
Ser -11	-	expression tag
Met -10	-	expression tag
Thr -9	-	expression tag
Gly -8	-	expression tag
Gly -7	-	expression tag
Gln -6	-	expression tag
Gln -5	-	expression tag
Met -4	-	expression tag
Gly -3	-	expression tag
Arg -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	74681.4
Non-Polymers*	Number of molecules	11
	Total formula weight	1772.0
All*	Total formula weight	76453.4

*Water molecules are not included.