3TQ0
Crystal structure of Leishmania major dihydroorotate dehydrogenase in complex with fumarate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004152 | molecular_function | dihydroorotate dehydrogenase activity |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006106 | biological_process | fumarate metabolic process |
| A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| A | 0006222 | biological_process | UMP biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
| A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| A | 0097014 | cellular_component | ciliary plasm |
| A | 1990663 | molecular_function | dihydroorotate dehydrogenase (fumarate) activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004152 | molecular_function | dihydroorotate dehydrogenase activity |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006106 | biological_process | fumarate metabolic process |
| B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| B | 0006222 | biological_process | UMP biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
| B | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| B | 0097014 | cellular_component | ciliary plasm |
| B | 1990663 | molecular_function | dihydroorotate dehydrogenase (fumarate) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE FMN A 313 |
| Chain | Residue |
| A | ALA19 |
| A | LYS165 |
| A | ILE194 |
| A | ASN195 |
| A | GLY222 |
| A | GLY223 |
| A | VAL226 |
| A | CYS249 |
| A | GLY250 |
| A | GLY251 |
| A | GLY272 |
| A | ALA20 |
| A | THR273 |
| A | FUM314 |
| A | HOH334 |
| A | HOH341 |
| A | HOH357 |
| A | HOH365 |
| A | GLY21 |
| A | LYS44 |
| A | SER45 |
| A | TYR59 |
| A | ASN68 |
| A | MET70 |
| A | ASN128 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE FUM A 314 |
| Chain | Residue |
| A | LYS44 |
| A | ASN68 |
| A | MET70 |
| A | GLY71 |
| A | LEU72 |
| A | ASN128 |
| A | CYS131 |
| A | PRO132 |
| A | ASN133 |
| A | ASN195 |
| A | FMN313 |
| A | HOH356 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 315 |
| Chain | Residue |
| A | VAL202 |
| A | ILE203 |
| A | HOH390 |
| A | HOH418 |
| B | LEU227 |
| B | LEU231 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE NI A 316 |
| Chain | Residue |
| A | HOH389 |
| B | HOH390 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 317 |
| Chain | Residue |
| A | PRO159 |
| A | HIS160 |
| A | SER161 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 318 |
| Chain | Residue |
| A | PRO159 |
| A | LYS187 |
| A | HOH459 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 319 |
| Chain | Residue |
| A | ARG239 |
| A | THR311 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 320 |
| Chain | Residue |
| A | TYR238 |
| A | ARG306 |
| A | HOH470 |
| A | HOH501 |
| site_id | AC9 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE FMN B 313 |
| Chain | Residue |
| B | ALA19 |
| B | ALA20 |
| B | GLY21 |
| B | LYS44 |
| B | SER45 |
| B | TYR59 |
| B | ASN68 |
| B | MET70 |
| B | ASN128 |
| B | LYS165 |
| B | ILE194 |
| B | ASN195 |
| B | GLY222 |
| B | GLY223 |
| B | VAL226 |
| B | CYS249 |
| B | GLY250 |
| B | GLY251 |
| B | GLY272 |
| B | THR273 |
| B | FUM314 |
| B | HOH343 |
| B | HOH353 |
| B | HOH355 |
| B | HOH368 |
| site_id | BC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE FUM B 314 |
| Chain | Residue |
| B | LYS44 |
| B | ASN68 |
| B | MET70 |
| B | GLY71 |
| B | LEU72 |
| B | ASN128 |
| B | CYS131 |
| B | PRO132 |
| B | ASN133 |
| B | ASN195 |
| B | FMN313 |
| B | HOH349 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 315 |
| Chain | Residue |
| B | HOH441 |
| A | LEU227 |
| A | LEU231 |
| B | VAL202 |
| B | ILE203 |
| B | HOH354 |
