3TOP

Crystral Structure of the C-terminal Subunit of Human Maltase-Glucoamylase in Complex with Acarbose

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Maltase-glucoamylase, intestinal	polymer	908	103727.2	2	UniProt (O43451) Pfam (PF00088) Pfam (PF01055) Pfam (PF21365)	Homo sapiens (human)	MGAM, Maltase, Alpha-glucosidase, Glucoamylase, Glucan 1,4-alpha-glucosidase
2	C, D (C, D)	4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose	branched		645.6	2	In PDB BIRD (PRD_900007) GlyTouCan (G66431MI)		alpha-acarbose
3	E, F (A, B)	water	water		18.0	38	Chemie (HOH)

Sequence modifications

A, B: 960 - 1853 (UniProt: O43451)

PDB	External Database	Details
Trp 952	-	expression tag
Ser 953	-	expression tag
His 954	-	expression tag
Pro 955	-	expression tag
Gln 956	-	expression tag
Phe 957	-	expression tag
Glu 958	-	expression tag
Lys 959	-	expression tag
His 1854	-	expression tag
His 1855	-	expression tag
His 1856	-	expression tag
His 1857	-	expression tag
His 1858	-	expression tag
His 1859	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	207454.4
Branched	Number of molecules	2
	Total formula weight	1291.2
All*	Total formula weight	208745.6

*Water molecules are not included.