3TNZ

Crystal structure of Mus musculus iodotyrosine deiodinase (IYD) C217A, C239A bound to FMN and mono-iodotyrosine (MIT)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Iodotyrosine dehalogenase 1	polymer	259	29923.3	2	UniProt (Q9DCX8) Pfam (PF00881)	Mus musculus (mouse)	IYD-1
2	C, H (A, B)	FLAVIN MONONUCLEOTIDE	non-polymer		456.3	2	Chemie (FMN)
3	D, I (A, B)	3-IODO-TYROSINE	non-polymer		307.1	2	Chemie (IYR)
4	E, J (A, B)	CITRATE ANION	non-polymer		189.1	2	Chemie (FLC)
5	F, G (A, B)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
6	K, L (A, B)	water	water		18.0	298	Chemie (HOH)

Sequence modifications

A, B: 34 - 285 (UniProt: Q9DCX8)

PDB	External Database	Details
Met 33	-	initiating methionine
Ala 217	Cys 217	engineered mutation
Ala 239	Cys 239	engineered mutation
His 286	-	expression tag
His 287	-	expression tag
His 288	-	expression tag
His 289	-	expression tag
His 290	-	expression tag
His 291	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	59846.5
Non-Polymers*	Number of molecules	8
	Total formula weight	2089.2
All*	Total formula weight	61935.8

*Water molecules are not included.