3TNZ
Crystal structure of Mus musculus iodotyrosine deiodinase (IYD) C217A, C239A bound to FMN and mono-iodotyrosine (MIT)
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE FMN A 301 |
| Chain | Residue |
| A | HOH9 |
| A | VAL232 |
| A | THR233 |
| A | THR234 |
| A | THR235 |
| A | LEU273 |
| A | ARG275 |
| A | IYR302 |
| A | HOH361 |
| B | PRO123 |
| B | SER124 |
| A | HOH11 |
| B | GLY125 |
| B | HIS127 |
| B | TYR208 |
| B | ILE211 |
| B | SER212 |
| A | HOH30 |
| A | ARG96 |
| A | ARG97 |
| A | SER98 |
| A | ARG100 |
| A | LEU172 |
| A | THR174 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE IYR A 302 |
| Chain | Residue |
| A | GLU153 |
| A | TYR157 |
| A | LEU169 |
| A | THR174 |
| A | ASN175 |
| A | LYS178 |
| A | THR235 |
| A | FMN301 |
| A | HOH334 |
| B | ALA126 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FLC A 303 |
| Chain | Residue |
| A | HIS106 |
| A | PRO108 |
| A | MET109 |
| A | HOH392 |
| B | ARG83 |
| B | HOH396 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 304 |
| Chain | Residue |
| A | TYR207 |
| A | TYR208 |
| B | LEU237 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL B 304 |
| Chain | Residue |
| A | LEU237 |
| B | TYR207 |
| B | TYR208 |
| site_id | AC6 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE FMN B 301 |
| Chain | Residue |
| A | PRO123 |
| A | SER124 |
| A | GLY125 |
| A | HIS127 |
| A | TYR208 |
| A | SER212 |
| B | HOH10 |
| B | HOH20 |
| B | ARG96 |
| B | ARG97 |
| B | SER98 |
| B | ARG100 |
| B | THR174 |
| B | VAL232 |
| B | THR233 |
| B | THR234 |
| B | THR235 |
| B | ARG275 |
| B | HOH294 |
| B | HOH295 |
| B | IYR302 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE IYR B 302 |
| Chain | Residue |
| A | ALA126 |
| B | GLU153 |
| B | TYR157 |
| B | LEU169 |
| B | THR174 |
| B | ASN175 |
| B | LYS178 |
| B | THR235 |
| B | FMN301 |
| B | HOH354 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FLC B 303 |
| Chain | Residue |
| A | ARG83 |
| B | HIS106 |
| B | PRO108 |
| B | MET109 |
| B | HOH300 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19436071","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22238141","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3GB5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GFD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GH8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3TNZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3TO0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"3GFD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3TNZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19436071","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22238141","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3GFD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3TNZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
