3TNQ
Structure and Allostery of the PKA RIIb Tetrameric Holoenzyme
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Protein kinase, cAMP-dependent, catalytic, alpha | polymer | 350 | 40817.3 | 1 | UniProt (A1L1M0) Pfam (PF00069) UniProt (by SIFTS) (P27791) | Rattus norvegicus (rat) | |
| 2 | B (A) | cAMP-dependent protein kinase type II-beta regulatory subunit | polymer | 416 | 46273.9 | 1 | UniProt (P31324) Pfam (PF02197) Pfam (PF00027) | Mus musculus (mouse) | |
| 3 | C, D (B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | E (B) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 5 | F, G (B, A) | water | water | 18.0 | 13 | Chemie (HOH) |
Sequence modifications
B: 1 - 350 (UniProt: A1L1M0)
A: 1 - 416 (UniProt: P31324)
| PDB | External Database | Details |
|---|---|---|
| Gln 42 | His 43 | CONFLICT |
| Ala 124 | Pro 125 | CONFLICT |
| PDB | External Database | Details |
|---|---|---|
| Lys 230 | Arg 230 | ENGINEERED MUTATION |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 87091.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 475.8 | |
| All* | Total formula weight | 87567.0 |
