3TNQ
Structure and Allostery of the PKA RIIb Tetrameric Holoenzyme
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001932 | biological_process | regulation of protein phosphorylation |
| A | 0004862 | molecular_function | cAMP-dependent protein kinase inhibitor activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005813 | cellular_component | centrosome |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005952 | cellular_component | cAMP-dependent protein kinase complex |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0007189 | biological_process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| A | 0007612 | biological_process | learning |
| A | 0008603 | molecular_function | cAMP-dependent protein kinase regulator activity |
| A | 0019901 | molecular_function | protein kinase binding |
| A | 0019904 | molecular_function | protein domain specific binding |
| A | 0030425 | cellular_component | dendrite |
| A | 0030552 | molecular_function | cAMP binding |
| A | 0031625 | molecular_function | ubiquitin protein ligase binding |
| A | 0034236 | molecular_function | protein kinase A catalytic subunit binding |
| A | 0043025 | cellular_component | neuronal cell body |
| A | 0043197 | cellular_component | dendritic spine |
| A | 0043198 | cellular_component | dendritic shaft |
| A | 0045859 | biological_process | regulation of protein kinase activity |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
| A | 0050804 | biological_process | modulation of chemical synaptic transmission |
| A | 0097332 | biological_process | response to antipsychotic drug |
| A | 0097546 | cellular_component | ciliary base |
| A | 0098794 | cellular_component | postsynapse |
| A | 0098978 | cellular_component | glutamatergic synapse |
| A | 0141162 | biological_process | negative regulation of cAMP/PKA signal transduction |
| B | 0001669 | cellular_component | acrosomal vesicle |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004674 | molecular_function | protein serine/threonine kinase activity |
| B | 0004691 | molecular_function | cAMP-dependent protein kinase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0005952 | cellular_component | cAMP-dependent protein kinase complex |
| B | 0006338 | biological_process | chromatin remodeling |
| B | 0006468 | biological_process | protein phosphorylation |
| B | 0007189 | biological_process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| B | 0008284 | biological_process | positive regulation of cell population proliferation |
| B | 0016020 | cellular_component | membrane |
| B | 0018105 | biological_process | peptidyl-serine phosphorylation |
| B | 0019901 | molecular_function | protein kinase binding |
| B | 0031267 | molecular_function | small GTPase binding |
| B | 0031514 | cellular_component | motile cilium |
| B | 0031594 | cellular_component | neuromuscular junction |
| B | 0032991 | cellular_component | protein-containing complex |
| B | 0034237 | molecular_function | protein kinase A regulatory subunit binding |
| B | 0034605 | biological_process | cellular response to heat |
| B | 0036126 | cellular_component | sperm flagellum |
| B | 0043457 | biological_process | regulation of cellular respiration |
| B | 0044877 | molecular_function | protein-containing complex binding |
| B | 0048471 | cellular_component | perinuclear region of cytoplasm |
| B | 0048792 | biological_process | spontaneous exocytosis of neurotransmitter |
| B | 0051447 | biological_process | negative regulation of meiotic cell cycle |
| B | 0051966 | biological_process | regulation of synaptic transmission, glutamatergic |
| B | 0098793 | cellular_component | presynapse |
| B | 0098794 | cellular_component | postsynapse |
| B | 0106310 | molecular_function | protein serine kinase activity |
| B | 0140198 | molecular_function | histone H1-4S35 kinase activity |
| B | 1904262 | biological_process | negative regulation of TORC1 signaling |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG B 402 |
| Chain | Residue |
| A | SEP112 |
| B | ASN171 |
| B | ASP184 |
| B | ADP400 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG B 401 |
| Chain | Residue |
| A | SEP112 |
| B | ASP184 |
| B | ADP400 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE ADP B 400 |
| Chain | Residue |
| B | VAL57 |
| B | ALA70 |
| B | LYS72 |
| B | MET120 |
| B | GLU121 |
| B | TYR122 |
| B | VAL123 |
| B | GLU127 |
| B | GLU170 |
| B | ASN171 |
| B | LEU173 |
| B | THR183 |
| B | ASP184 |
| B | PHE327 |
| B | MG401 |
| B | MG402 |
| A | SEP112 |
| B | GLY52 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGTGSFGRVMlVkhkesgnh..........YAMK |
| Chain | Residue | Details |
| B | LEU49-LYS72 |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. LiYrDLKpeNLLI |
| Chain | Residue | Details |
| B | LEU162-ILE174 |
| site_id | PS00888 |
| Number of Residues | 17 |
| Details | CNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. VIdQGDdGDnFYVIdrG |
| Chain | Residue | Details |
| A | VAL179-GLY195 | |
| A | ILE301-GLY317 |
| site_id | PS00889 |
| Number of Residues | 18 |
| Details | CNMP_BINDING_2 Cyclic nucleotide-binding domain signature 2. FGElALvtnkp......RAAsAhA |
| Chain | Residue | Details |
| A | PHE348-ALA365 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P17612","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P05132","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine; by PDPK1","evidences":[{"source":"UniProtKB","id":"P00517","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P05132","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"22673903","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 121 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"16452087","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"17242355","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19131326","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
