3TMH
Crystal structure of dual-specific A-kinase anchoring protein 2 in complex with cAMP-dependent protein kinase A type II alpha and PDZK1
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, E, I | Na(+)/H(+) exchange regulatory cofactor NHE-RF3 | polymer | 87 | 9277.6 | 3 | UniProt (Q5T2W1) Pfam (PF00595) In PDB | Homo sapiens (human) | NHERF-3, CFTR-associated protein of 70 kDa, Na(+)/H(+) exchanger regulatory factor 3, Na/Pi cotransporter C-terminal-associated protein 1, NaPi-Cap1, PDZ domain-containing protein 1, Sodium-hydrogen exchanger regulatory factor 3 |
2 | B, C, F, G | cAMP-dependent protein kinase type II-alpha regulatory subunit | polymer | 48 | 5542.3 | 4 | UniProt (P12368) Pfam (PF02197) In PDB | Rattus norvegicus (brown rat rat rats) | |
3 | D, H, L | A-kinase anchor protein 10, mitochondrial | polymer | 45 | 5086.7 | 3 | UniProt (O43572) In PDB | Homo sapiens (human) | AKAP-10, Dual specificity A kinase-anchoring protein 2, D-AKAP-2, Protein kinase A-anchoring protein 10, PRKA10 |
4 | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence modifications
A, E, I: 375 - 459 (UniProt: Q5T2W1)
B, C, F, G: 0 - 44 (UniProt: P12368)
D, H, L: 623 - 662 (UniProt: O43572)
PDB | External Database | Details |
---|---|---|
Gly 373 | - | expression tag |
Ser 374 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly -3 | - | expression tag |
Ser -2 | - | expression tag |
His -1 | - | expression tag |
Gly 1 | Ser 2 | conflict |
PDB | External Database | Details |
---|---|---|
Gly 618 | - | expression tag |
Ser 619 | - | expression tag |
Pro 620 | - | expression tag |
Glu 621 | - | expression tag |
Phe 622 | - | expression tag |
Val 646 | Ile 646 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 10 |
Total formula weight | 65262.1 | |
All* | Total formula weight | 65262.1 |