3TL5
Discovery of GDC-0980: a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor for the Treatment of Cancer
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | polymer | 966 | 110727.1 | 1 | UniProt (P48736) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454) In PDB | Homo sapiens (human) | Phosphoinositide 3-kinase p110-gamma-isoform, PI3-kinase subunit gamma, PI3K-gamma, PtdIns-3-kinase subunit gamma, Phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma, PtdIns-3-kinase subunit p110-gamma, p120-PI3K |
2 | A | (2S)-1-(4-{[2-(2-aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl}piperazin-1-yl)-2-hydroxypropan-1-one | non-polymer | 498.6 | 1 | Chemie (980) | |||
3 | water | water | 18.0 | 13 | Chemie (HOH) |
Sequence modifications
A: 144 - 1102 (UniProt: P48736)
PDB | External Database | Details |
---|---|---|
Met 143 | - | expression tag |
His 1103 | - | expression tag |
His 1104 | - | expression tag |
His 1105 | - | expression tag |
His 1106 | - | expression tag |
His 1107 | - | expression tag |
His 1108 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 110727.1 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 498.6 | |
All* | Total formula weight | 111225.7 |