3TGU

Cytochrome bc1 complex from chicken with pfvs-designed moa inhibitor bound

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, K (A, N)	Mitochondrial ubiquinol-cytochrome-c reductase complex core protein i	polymer	446	49503.8	2	UniProt (D0VX31) Pfam (PF00675) Pfam (PF05193)	Gallus gallus (bantam chickens)	UQCRC1
2	B, L (B, O)	Mitochondrial ubiquinol-cytochrome-c reductase complex core protein 2	polymer	441	46683.8	2	UniProt (D0VX29) Pfam (PF00675) Pfam (PF05193)	Gallus gallus (bantam chickens)	UQCRC2
3	C, M (C, P)	Cytochrome b	polymer	380	42651.0	2	UniProt (P18946) Pfam (PF00033) Pfam (PF00032)	Gallus gallus (bantam chickens)	Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
4	D, N (D, Q)	Mitochondrial cytochrome c1, heme protein	polymer	241	26973.7	2	UniProt (D0VX26) Pfam (PF02167)	Gallus gallus (bantam chickens)
5	E, O (E, R)	Cytochrome b-c1 complex subunit Rieske, mitochondrial	polymer	196	21506.2	2	UniProt (Q5ZLR5) Pfam (PF02921) Pfam (PF00355)	Gallus gallus (bantam chickens)	Complex III subunit 5, Rieske iron-sulfur protein, RISP, Ubiquinol-cytochrome c reductase iron-sulfur subunit
6	F, P (F, S)	Mitochondrial ubiquinol-cytochrome c reductase 14 kda protein	polymer	110	13394.4	2	UniProt (D0VX30) Pfam (PF02271)	Gallus gallus (bantam chickens)	UQCRB
7	G, Q (G, T)	Mitochondrial ubiquinol-cytochrome c reductase ubiquinone-binding protein qp-c	polymer	81	9498.7	2	UniProt (D0VX32) Pfam (PF02939)	Gallus gallus (bantam chickens)	UQCRQ
8	H, R (H, U)	Mitochondrial ubiquinol-cytochrome c reductase 11 kda protein, complex iii subunit viii	polymer	77	9057.1	2	UniProt (D0VX28) Pfam (PF02320)	Gallus gallus (bantam chickens)	UQCRH, HINGE PROTEIN
9	I, S (I, V)	Cytochrome b-c1 complex subunit Rieske, mitochondrial	polymer	76	7721.1	2	UniProt (Q5ZLR5) Pfam (PF09165)	Gallus gallus (bantam chickens)	Complex III subunit 5, Rieske iron-sulfur protein, RISP, Ubiquinol-cytochrome c reductase iron-sulfur subunit
10	J, T (J, W)	Mitochondrial ubiquinol-cytochrome c reductase 7.2 kda protein	polymer	61	7006.0	2	UniProt (D0VX27) Pfam (PF05365)	Gallus gallus (bantam chickens)	UQCR10
11	JA, U (N, A)	UNKNOWN LIGAND	non-polymer			2	Chemie (UNL)
12	LA, MA, V, W (P, C)	PROTOPORPHYRIN IX CONTAINING FE	non-polymer		616.5	4	Chemie (HEM)
13	OA, X (P, C)	methyl (2E)-3-methoxy-2-[2-({[6-methyl-3-(trifluoromethyl)quinoxalin-2-yl]oxy}methyl)phenyl]prop-2-enoate	non-polymer		432.4	2	Chemie (WF3)
14	PA, Y (P, C)	Coenzyme Q10, (2Z,6E,10Z,14E,18E,22E,26Z)-isomer	non-polymer		863.3	2	Chemie (UQ)
15	IA, QA, UA, Z (G, P, Q, C)	CARDIOLIPIN	non-polymer		1464.0	4	Chemie (CDL)
16	AA, BA, HA, KA, RA... (C, E, N, P, R)	1,2-dioleoyl-sn-glycero-3-phosphoethanolamine	non-polymer		744.0	6	Chemie (PEE)
17	CA, SA (C, P)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
18	DA, TA (D, Q)	HEME C	non-polymer		618.5	2	Chemie (HEC)
19	EA, FA, NA, VA, WA (D, P, Q)	octyl beta-D-glucopyranoside	non-polymer		292.4	5	Chemie (BOG)
20	GA, XA (E, R)	FE2/S2 (INORGANIC) CLUSTER	non-polymer		175.8	2	Chemie (FES)
21	AB, BB, CB, ZA (E, P, R, C)	water	water		18.0	21	Chemie (HOH)

Sequence modifications

C, P: 2 - 380 (UniProt: P18946)

PDB	External Database	Details
Fme 1	-	initiating methionine

I, V: 2 - 8 (UniProt: Q5ZLR5)
I, V: 50 - 78 (UniProt: Q5ZLR5)

Contents of the asymmetric unit

Polymers	Number of chains	20
	Total formula weight	467991.7
Non-Polymers*	Number of molecules	31
	Total formula weight	18612.5
All*	Total formula weight	486604.2

*Water molecules are not included.