Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3TGU

Cytochrome bc1 complex from chicken with pfvs-designed moa inhibitor bound

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005739	cellular_component	mitochondrion
A	0046872	molecular_function	metal ion binding
B	0005739	cellular_component	mitochondrion
B	0046872	molecular_function	metal ion binding
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0005750	cellular_component	mitochondrial respiratory chain complex III
C	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
C	0006979	biological_process	response to oxidative stress
C	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
C	0009055	molecular_function	electron transfer activity
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0020037	molecular_function	heme binding
C	0022904	biological_process	respiratory electron transport chain
C	0045275	cellular_component	respiratory chain complex III
C	0046872	molecular_function	metal ion binding
C	0070469	cellular_component	respirasome
C	1902600	biological_process	proton transmembrane transport
D	0005739	cellular_component	mitochondrion
D	0005743	cellular_component	mitochondrial inner membrane
D	0005750	cellular_component	mitochondrial respiratory chain complex III
D	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
D	0009055	molecular_function	electron transfer activity
D	0016020	cellular_component	membrane
D	0020037	molecular_function	heme binding
D	0046872	molecular_function	metal ion binding
D	0070469	cellular_component	respirasome
E	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
E	0016020	cellular_component	membrane
E	0051537	molecular_function	2 iron, 2 sulfur cluster binding
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0005750	cellular_component	mitochondrial respiratory chain complex III
F	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
F	0016020	cellular_component	membrane
F	0070469	cellular_component	respirasome
G	0005739	cellular_component	mitochondrion
G	0005743	cellular_component	mitochondrial inner membrane
G	0005750	cellular_component	mitochondrial respiratory chain complex III
G	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
G	0016020	cellular_component	membrane
G	0070469	cellular_component	respirasome
H	0005739	cellular_component	mitochondrion
H	0005743	cellular_component	mitochondrial inner membrane
H	0005750	cellular_component	mitochondrial respiratory chain complex III
H	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
H	0016020	cellular_component	membrane
H	0070469	cellular_component	respirasome
I	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
J	0005739	cellular_component	mitochondrion
J	0005743	cellular_component	mitochondrial inner membrane
J	0005750	cellular_component	mitochondrial respiratory chain complex III
J	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
J	0009060	biological_process	aerobic respiration
J	0016020	cellular_component	membrane
J	0070469	cellular_component	respirasome
N	0005739	cellular_component	mitochondrion
N	0046872	molecular_function	metal ion binding
O	0005739	cellular_component	mitochondrion
O	0046872	molecular_function	metal ion binding
P	0005737	cellular_component	cytoplasm
P	0005739	cellular_component	mitochondrion
P	0005743	cellular_component	mitochondrial inner membrane
P	0005750	cellular_component	mitochondrial respiratory chain complex III
P	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
P	0006979	biological_process	response to oxidative stress
P	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
P	0009055	molecular_function	electron transfer activity
P	0016020	cellular_component	membrane
P	0016491	molecular_function	oxidoreductase activity
P	0020037	molecular_function	heme binding
P	0022904	biological_process	respiratory electron transport chain
P	0045275	cellular_component	respiratory chain complex III
P	0046872	molecular_function	metal ion binding
P	0070469	cellular_component	respirasome
P	1902600	biological_process	proton transmembrane transport
Q	0005739	cellular_component	mitochondrion
Q	0005743	cellular_component	mitochondrial inner membrane
Q	0005750	cellular_component	mitochondrial respiratory chain complex III
Q	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
Q	0009055	molecular_function	electron transfer activity
Q	0016020	cellular_component	membrane
Q	0020037	molecular_function	heme binding
Q	0046872	molecular_function	metal ion binding
Q	0070469	cellular_component	respirasome
R	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
R	0016020	cellular_component	membrane
R	0051537	molecular_function	2 iron, 2 sulfur cluster binding
S	0005739	cellular_component	mitochondrion
S	0005743	cellular_component	mitochondrial inner membrane
S	0005750	cellular_component	mitochondrial respiratory chain complex III
S	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
S	0016020	cellular_component	membrane
S	0070469	cellular_component	respirasome
T	0005739	cellular_component	mitochondrion
T	0005743	cellular_component	mitochondrial inner membrane
T	0005750	cellular_component	mitochondrial respiratory chain complex III
T	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
T	0016020	cellular_component	membrane
T	0070469	cellular_component	respirasome
U	0005739	cellular_component	mitochondrion
U	0005743	cellular_component	mitochondrial inner membrane
U	0005750	cellular_component	mitochondrial respiratory chain complex III
U	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
U	0016020	cellular_component	membrane
U	0070469	cellular_component	respirasome
V	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
W	0005739	cellular_component	mitochondrion
W	0005743	cellular_component	mitochondrial inner membrane
W	0005750	cellular_component	mitochondrial respiratory chain complex III
W	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
W	0009060	biological_process	aerobic respiration
W	0016020	cellular_component	membrane
W	0070469	cellular_component	respirasome

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	54
Details	TOPO_DOM: Mitochondrial matrix => ECO:0000250\|UniProtKB:P13272

Chain	Residue	Details
E	VAL1-SER28
P	TRP78-ILE99
P	TRP114-LEU134
P	PHE179-THR199
P	PHE227-SER247
P	LEU289-HIS309
P	LEU321-SER341
P	PHE348-PRO368
R	VAL1-SER28
C	TRP114-LEU134
C	PHE179-THR199
C	PHE227-SER247
C	LEU289-HIS309
C	LEU321-SER341
C	PHE348-PRO368
P	PHE34-MET54

site_id	SWS_FT_FI2
Number of Residues	66
Details	TRANSMEM: Helical => ECO:0000269\|PubMed:9565029

Chain	Residue	Details
E	SER29-LEU62
R	SER29-LEU62

site_id	SWS_FT_FI3
Number of Residues	266
Details	TOPO_DOM: Mitochondrial intermembrane => ECO:0000250\|UniProtKB:P13272

Chain	Residue	Details
E	SER63-GLY196
R	SER63-GLY196
P	HIS98
P	HIS197

site_id	SWS_FT_FI4
Number of Residues	10
Details	BINDING: BINDING => ECO:0000269\|PubMed:9565029, ECO:0007744\|PDB:3H1H, ECO:0007744\|PDB:3H1I, ECO:0007744\|PDB:3H1J

Chain	Residue	Details
E	CYS139
R	SER163
E	HIS141
E	CYS158
E	HIS161
E	SER163
R	CYS139
R	HIS141
R	CYS158
R	HIS161

site_id	SWS_FT_FI5
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:9565029, ECO:0007744\|PDB:3H1H, ECO:0007744\|PDB:3H1I

Chain	Residue	Details
E	LEU142
R	LEU142

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)