3TDJ

Crystal structure of the GluA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and BPAM-97 at 1.95 A resolution

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Glutamate receptor 2	polymer	263	29244.7	2	UniProt (P19491) Pfam (PF10613) Pfam (PF00060) In PDB	Rattus norvegicus (rat)	GluR-2, AMPA-selective glutamate receptor 2, GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA 2, GluA2
2	A, B	GLUTAMIC ACID	non-polymer		147.1	2	Chemie (GLU)
3	A, B	SULFATE ION	non-polymer		96.1	3	Chemie (SO4)
4	A, B	CHLORIDE ION	non-polymer		35.5	5	Chemie (CL)
5	A, B	GLYCEROL	non-polymer		92.1	11	Chemie (GOL)
6	B	4-ethyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide	non-polymer		230.3	2	Chemie (3TJ)
7		water	water		18.0	518	Chemie (HOH)

Sequence modifications

A, B: 3 - 117 (UniProt: P19491)

PDB	External Database	Details
Gly 1	-	expression tag
Ala 2	-	expression tag
Tyr 94	Leu 504	engineered mutation

A, B: 120 - 263 (UniProt: P19491)

PDB	External Database	Details
Gly 118	-	linker
Thr 119	-	linker
Ser 242	Asn 775	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	58489.4
Non-Polymers*	Number of molecules	23
	Total formula weight	2233.3
All*	Total formula weight	60722.6

*Water molecules are not included.